低钠盐饮食对胰岛素信号通路相关基因网络状态的影响  

THE EFFECT OF LOW-SODIUM-SALT INTAKE ON EXPRESSION STATUS OF GENE NETWORK RELATED TO INSULIN SIGNALING PATHWAY

作　　者：张治洲[1] 常丽君[1] 王秀锦[1] 阎大伟[1] 王艳萍[1] 

机构地区：[1]天津科技大学食品工程与生物技术学院泰达BIO-X系统生物技术研究中心营养基因组学与功能食品研究所,天津300457

出　　处：《食品研究与开发》2008年第1期62-67,共6页Food Research and Development

基　　金：2006教育部新世纪优秀人才计划和上海川崎集团药食同源研究基金支持.

摘　　要：研究低钠盐饮食对高血压与肥胖并发者血液中胰岛素信号通路相关基因表达的影响,初步找到表达发生变化的基因间相互关联的网络状态。选择3名高血压与肥胖并发者,分别对他们食用低钠盐前后的血样做胰岛素信号通路表达谱芯片,共6张。以每个受试者食用前所做芯片图做对照,找出其食用后表达发生变化的基因。在检测的144个基因中,得到2次以上重复一致的异常表达基因共26条:上调基因6个,下调基因20个。食用低钠盐对胰岛素信号传导通路中的Focal Adhesion通路和PI3K途径有直接的影响,上述结果从血液基因表达的层面和局部基因网络的角度提供了食低钠盐缓减胰岛素抵抗的初步证据。To investigate the effect of low-sodium-salt on expression of genes related to insulin signaling pathway among the patients with obesity and high blood pressure,and to set up a local gene network model.Three patients with obesity and high blood pressure were chosen.The peripheral blood taken before and after consuming low-sodium salt,were used to analyze the differences of the gene expression by Oligo Insulin Signaling Pathway SuperAarray,six chips in total.Among the 144 genes,there were 26 differentially expressed,with 6 genes up-regulated and 22 genes down-regulated.Low-sodium salt consumption may affect activities of focal adhesion and PI3K pathway,providing an initial model of local gene network that describes how low-sodium salt intake moderates the level of insulin resistance and improves body status of obesity/hypertension people.

关 键 词：胰岛素抵抗 低钠盐 胰岛素信号通路 表达谱芯片 局部网络 

分 类 号：R544.1[医药卫生—心血管疾病] R589.2[医药卫生—内科学]