食管癌患者术前放化疗对其术后全身性炎症反应的影响  

Study on the contribution of preoperative chemoradiotherapy for advanced esophageal cancer to the postoperative systemic inflammatory response

作　　者：杨帆[1] 马海涛[1] 朱建军[1] 

机构地区：[1]苏州大学附属第一医院,江苏省苏州市215003

出　　处：《实用诊断与治疗杂志》2008年第1期1-3,共3页Journal of Practical Diagnosis and Therapy

摘　　要：目的:探讨食管癌患者术前放化疗对术后全身炎症反应的影响。方法:2005年7月-2007年4月连续收治符合入组条件的中晚期食管鳞癌患者42例,将其随机分为术前放化疗(CRT)组和单纯手术(SA)组,CRT组术前采用DDP+盖诺化疗方案和同期常规分割放疗,间隔3～5周行手术,SA组行单纯手术。结果:术前放化疗患者的全身性炎症反应综合征(SIRS)发生率和持续时间明显高于单纯食管癌切除术患者(P<0.05)。结论:术前放化疗能明显加重患者术后全身炎症反应综合征,从而增加并发症风险。Objective To approach the effect of preoperative chemoradiotherapy on the postoperative systemic inflammatory response.Methods Forty-two patients with advanced esophageal squamous carcinoma were divided into CRT group（preoperative chemoradiotherapy） and SA group（surgery alone）.CRT group underwent vinorelbine bitartrate injection combined with DDP chemotherapy and DT 40 Gy radiotherapy for four weeks,and operations were performed in 3 to 5 weeks after chemoradiotherapy.SA group underwent operations directly.Results The duration and incidence of postoperative systemic inflammatory response in CRT group were significantly greater than those in SA group（P〈0.05）.Conclusion Preoperative chemoradiotherapy may significantly enhance postoperative systemic inflammatory response syndrome,suggesting its potentially higher risk of complications.

关 键 词：食管癌 放化疗 全身炎症反应综合征 

分 类 号：R735.1[医药卫生—肿瘤]