乳腺浸润性导管癌中Hpa和C-erbB-2联合表达与淋巴结转移的关系  

Correlation Between Lymph-node Metastasis and Combined Expression of Hpa and C-erbB-2 of Invasive Ductal Breast Carcinoma

作　　者：郑晓东[1] 肖春波 毛大华[3] 

机构地区：[1]重庆市肿瘤研究所乳腺科,重庆400030 [2]重庆市铜梁县妇幼保健院 [3]贵阳医学院附属医院乳腺科

出　　处：《四川大学学报（医学版）》2008年第1期52-54,共3页Journal of Sichuan University(Medical Sciences)

摘　　要：目的了解乙酰肝素酶(Hpa)、癌基因(C-erbB-2)在乳腺浸润性导管癌中联合表达与淋巴结转移的关系。方法选用经手术切除乳腺纤维腺瘤标本14例,乳腺浸润性导管癌标本81例,采用免疫组织化学的方法检测Hpa、C-erbB-2在两组标本中的表达,分析两因子不同表达状况与乳腺浸润性导管癌淋巴结转移数目的关系及两因子间的相互关系。结果在乳腺浸润性导管癌组中Hpa、C-erbB-2的阳性表达分别为52例(72.84%)、29例(35.80%),而在乳腺纤维腺瘤组中无表达(P<0.05);C-erbB-2的表达与Hpa的表达有关(P<0.05),且二者表达强度呈正相关(r=0.668,P<0.01);同时表达Hpa与C-erbB-2的肿瘤淋巴结转移高于单一表达Hpa或C-erbB-2者(P均<0.01)。结论Hpa可能促进了C-erbB-2蛋白的表达,二者共同作用可能促进了乳腺浸润性导管癌生长、浸润和转移。Objective This study is to learn the correlation between lymph-node metastasis and the combined expression of Heparanase （Hpa） and C-erbB-2. Methods The expressions of Hpa and C-erbB-2 were examined in 81 human invasive ductal breast carcinomas （ IDBC ） and 14 fibroadenomas by SP immunohistochemistry analysis. We analyzed the expressions of two factors in two groups, in which their correlation with lymph-node metastasis in IDBC was also studied. Results （1）Positive expressions of Hpa and CerbB-2 in IDBC tissue were 59（72. 84%） and 29（35. 80%） respectively, in which the positive expression rates were significantly higher than those in fibroadenomas （P= 0. 0000, 0. 0177）. （2）The expression of C-erbB-2 was correlated with Hpa expression（r=0. 668,P〈0. 01）. （3）When Hpa expression was combined with the status of C- erbB-2 expression, the lymph node metastasis with positive-Hpa and positive-C-erbB-2 expressions occurred significantly higher in patients with IDBC （all P〈0.01）. Conclusion Hpa may up-regulate the expression of C-erbB-2. Furthermore, as co-expression, Hpa and C-erbB-2 work together, which would take the possession of stronger role in the procedure of growth, invasion and metastasis of IDBC.

关 键 词：乙酰肝素酶 癌基因 乳腺肿瘤 淋巴结 转移 

分 类 号：R737.9[医药卫生—肿瘤]