同种异体复合骨重建椎体的生物力学实验研究  

Biomechanical Study of Vertebral Reconstruction with Allograft Compound Vertebra

作　　者：周庞虎[1] 刘世清[1] 明江华[1] 

机构地区：[1]武汉大学人民医院骨科,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2008年第1期17-19,58,共4页Medical Journal of Wuhan University

基　　金：湖北省自然科学基金资助项目(编号:2004ABA171)

摘　　要：目的:为椎体材料的研制与临床上选择重建材料提供生物力学的指导。方法:选择25只健康成年新西兰大耳白兔,随机分成3组,A组:正常对照组(NG)5只;B组:髂骨组(IBG)10只;C组:同种异体复合骨组(ACVG)10只,实验组B和C切除C4椎体后,分别植入自体三面皮质髂骨、同种异体皮质骨笼+自体松质骨,于术后1、2月随机抽取B、C组兔各5只进行离体轴向屈曲、伸展、侧弯、扭转状态下的载荷-应变?扭矩-扭角关系变化测试,各组间进行比较,并进行统计学处理。结果:C组的生物力学强度较好,手术后1月和2月的各项指标均和A组没有统计学差异(P>0.05);B组术后1月的力学稳定性明显低于A组和C组(P<0.05),但随着时间的推移,生物力学强度逐渐加强,到术后2月的时候,已和它们没有统计学差异(P>0.05);术后1月时,C组的力学稳定性优于B组(P<0.05),到术后2月的时候,它们的力学稳定性已没有统计学差异。结论:同种异体皮质骨笼和自体松质骨组成的复合骨,即时和永久的生物力学稳定性均较好,是一种理想的椎体重建材料。Objective： To study the bio-mechanical characteristics of new vertebral reconstruction materials. Methods： Twenty-five healthy big-ear white rabbits were randomly divided into three groups： group A（ normal group, n=5）, group B（iliac bone graft group, n= 10） and group C （allograft compound vertebra group,n= 10）. lliac bones were implanted in group B and allograft bone cages were transplanted in group C after C4 vertebras were resected. Five rabbits in group B and group C were respectively selected in one and two months at random after operation for the tests of the load-strain in flexion, extension, lateral bending and torque-torsion angle in torsion. Results： The biomechanical strength was good in group C, and no statistical difference was found between group C and group A in one and two months. The biomechanical strength of group B was less than that of group A and group C in one month, and no significant difference was found among the three groups in biomechanical strength results after two months. Conclusion： The compound vertebras reconstructed by allograft cortical bone cage and autogenous cancellous bone are ideal rebuilded materials for the instantaneous and permanent biomechanical stability.

关 键 词：复合骨 椎体重建 生物力学 兔 

分 类 号：R738.1[医药卫生—肿瘤]