奥氮平和利培酮对精神分裂症小鼠模型的作用  

The Effects of Risperidone and Olanzapine on the Schizophrenia Model in Mice

作　　者：谢青莲 邹洪 张臣颢 金玫蕾 

机构地区：[1]上海中科伍佰豪生物工程有限公司,上海200233

出　　处：《复旦学报（自然科学版）》2007年第6期925-929,共5页Journal of Fudan University：Natural Science

基　　金：国家自然科学基金资助项目(30270219)

摘　　要：利用精神分裂症小鼠模型比较临床上使用的非典型抗精神分裂症药物利培酮(Risperidone)和奥氮平(Olanzapine)的作用.试验结果:①利培酮和奥氮平都能有效地抑制小鼠的快速移动行为,高剂量的利培酮和奥氮平都能有效地抑制小鼠的刻板性行为;②利培酮的半最大效应浓度比奥氮平的半最大效应浓度小,表明其治疗效果更明显;③从共济失调副反应的半最大效应浓度与快速移动效应的半最大效应浓度的比值来看,利培酮的疗效也优于奥氮平.The effects of Risperidone and Olanzapine, which are wildly used as atypical antipsychoties in clinic, were compared by using the schizophrenia mice model induced by MK-801. Results show that both Risperidone and Olanzapine can effectively restrain hyperloccmotion induced by MK-801 in mice, and higher dose of Risperidone and Olanzapine can also restrain stereotype behavior induced by MK-801. The concentration for 50% of maximal effect （EC50） of Risperidone is lower than that of Olanzapine,which indicates that Risperidone is of much better therapeutic effect. And comparing with the ratio of EC50 of ataxia to EC50 of hyperlocomotion between Risperidone and Olanzapine, the result also supports the above conclusion.

关 键 词：MK-801 奥氮平 利培酮 快速移动 刻板性行为 共济失调 

分 类 号：Q42[生物学—神经生物学]