近红外光谱活体在位测量C6荷瘤鼠脑局部血氧饱和度  

In vivo measurement of local cerebral saturation of oxgen in C6 glioma loaded rats by near infrared spectroscopy

作　　者：李宽正[1] 杨天明[1] 钱志余[2] 戴丽娟[2] 李荣[2] 王杭州[1] 张亮[1] 

机构地区：[1]东南大学附属中大医院神经外科,210009 [2]南京航空航天大学生物医学工程系,210016

出　　处：《临床神经外科杂志》2007年第4期145-147,共3页Journal of Clinical Neurosurgery

基　　金：国家自然科学基金资助(30671997)

摘　　要：目的探讨新的近红外光谱技术来测量C6胶质瘤荷瘤鼠脑局部血氧饱和度(SO2)的特点。方法利用光学探头微创测量30只C6荷瘤鼠瘤体局部SO2,并与对侧脑组织SO2进行比较。结果瘤体内SO2较正常脑组织SO2低,两者差异有统计学意义(P<0.05);有坏死或出血个体SO2曲线出现明显低峰。结论通过微创光学探头可以测量胶质瘤内SO2。Objective To measure local cerebral blood oxygen saturation in C6 glioma rats in vivo by new near infrared spectroscopy （NIRS）. Methods 30 C6 glioma-bearing rats were measured mini-invasively by a optic fiber probe revealing SO2. Intratumoural SO2 （ tSO2 ） was compared to normal cerebral tissue SO2. Results The mean SO2 of intratumoural tissue was（55. 1 ± 4.7）%,and the mean SO2 of normal tissue was （60.7 ± 2.5）% in contralateral cerebral tissue, respeetively. The difference is significant, Conclusions Measurement of glioma in vivo by NIRS is feasible.

关 键 词：C6脑胶质瘤 血氧饱和度(SO2) 近红外光谱(NIRS) 

分 类 号：R730.264[医药卫生—肿瘤]