强迫症患者睡眠脑电图与认知功能改变的相关性研究  

A related study between polysomnography and cognition in patients with obsessive-compulsive disorder

作　　者：梅峰[1] 欧红霞[1] 王旸[2] 

机构地区：[1]南京医科大学附属脑科医院,南京210029 [2]山东大学医学院精神卫生研究所

出　　处：《精神医学杂志》2007年第6期343-345,共3页Journal of Psychiatry

摘　　要：目的探讨强迫症患者睡眠脑电图与认知功能改变的相关性。方法对20例强迫症患者(研究组)及20例正常对照个体(对照组)进行多导睡眠脑电图、P300及韦氏智测测定,并将研究组中睡眠脑电图各参数与P300及韦氏智测各指标进行相关分析。结果与对照组相比,研究组在多导睡眠脑电图的许多指标上均有显著性差异,表现为醒起时间长、醒觉时间长、运动觉醒时间长、觉睡比(%)高、睡眠效率(%)低、睡眠维持率(%)低、快速眼动睡眠(REM)睡眠时间少、睡眠结构的第一阶段时间明显延长;睡眠脑电图的指标与P300及韦氏智测存在不同的相关性。结论强迫症患者的睡眠脑电图改变与其事件相关诱发电位P300等认知功能指标有一定相关性。Objective To investigate the relationship between polysomnography and cognition in patients with obsessive-compulsive disorder （OCD） . Methods A total of 20 patients with OCD in study group and 20 normal person in control group were measured by polysomnography, event-related potentials P3QQ and Wechsler Adult Intelligence Scale（WAIS-RC）. Results There were more prolonged early morning awakening and awake time, increased motion awakening time and awake/sleep, reduced sleep efficiency and maintenance, shorted Rapid Eye Movement（REM） sleep time and increased percentage of stage 1 sleep in study group than that in control group. Conclusion The polysomnography in patients with OCD is related to event-related potentials P300 and intelligence.

关 键 词：强迫症 睡眠脑电图 认知功能 

分 类 号：R749.7[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]