齐拉西酮与氯氮平治疗精神分裂症兴奋激越症状的对照研究  

A comparative study of zipraside and clozapine in the treatment of schizophrenia with excitement and agitation

作　　者：曹江[1] 陶学良[1] 陈征[1] 田丽[1] 

机构地区：[1]天津市安定医院,300074

出　　处：《精神医学杂志》2007年第6期354-356,共3页Journal of Psychiatry

摘　　要：目的比较齐拉西酮与氯氮平治疗精神分裂症患者伴有兴奋激越的疗效与不良反应。方法符合CC-MD一3诊断标准的非首发精神分裂症住院患者,共80例,分为齐拉西酮组(试验组)40例,氯氮平组(对照组)40例,采用随机对照、开放性研究治疗两周。并以治疗前后简明精神病量表激越分减分率评定疗效,以副反应量表评估不良反应。结果两组在1周末和2周末BPRS激越分均较治疗前显著下降,2周末试验组有效率为70.0%,对照组有效率为72.5%,两组疗效相仿(P>0.05)。试验组不良反应较对照组少。结论齐拉西酮对精神分裂症兴奋激越症状的疗效与氯氮平相当,不良反应较小,安全性好。Objective To compare the efficacy and safety of zipraside with clozapine in the treatment of schizophrenia with excitement and agitation . Methods Eighty patients with schizophrenia were randomly treated with zipraside（120-160mg/d ）and clozapine（150--400 mg/d ）for 2 weeks. The Brief Psychiatric Rating scale （BPRS） and Treatment Emergent Symptom Scale（TESS）were used to measure the efficacy and safety . Results Compared with the baseline, the patients experienced significant improvement in BPRS scores at the end of both 1st and 2nd week. The effective rates of zipraside and clozapine were 70.0% and 72.5% respectively at the end of 2nd week and there had no significantly difference （P〉0.05）. The incidence of adverse events in zipraside group was significantly less than that in clozapine group patients. Conclusion Zipraside is as efficacious as clozapine in controlling excitement and agitation for patients with schizophrenia,with fewer adverse events.

关 键 词：齐拉西酮 氯氮平 激越 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]