抗癌中药对肺癌标记物表达的影响及其疗效分析  

Detecting the role Chinese herbs to the effect and machenism of lung cancer

作　　者：张洁霞[1] 毛小玲[1] 郑丽霞[1] 

机构地区：[1]广州医学院第一附属医院肿瘤血液中心,广东广州510120

出　　处：《中国医药导报》2008年第2期11-12,共2页China Medical Herald

摘　　要：目的:分析检测血液中癌胚抗原CEA mRNA、缓解率的变化,评价抗癌中药注射液对肺癌的疗效。方法:以肺癌(40例实验组、40例对照组)为对象,应用半巢式-聚合酶链反应技术检测患者注射抗癌中药前后血CEA mRNA水平、CR+PR+SD率。结果:治疗后,实验组CEA mRNA阳性结果为22.5%(9例),低于对照组的45%(18例)(P<0.05);CR+PR+SD率上升达80.0%(P<0.05)。结论:抗癌中药可有效治疗肺癌,CEA mRNA阳性例数减少,提高了临床有效率。Objective：To detect both the gene CEA mRNA and the remission rate of Chinese herbs in lung cancer. Methods： Both the experiment group and the control included 40 cases. CEA mRNA gene analysis was performed by se- mi-nested-polymerase chain reaction before and after treatment.The remission rate was observed. Results：The CEA mR- NA positive rate 22.5%（9 cases） of the experimental group was lower than the control one＇s 45%（18 cases）（P〈0.05）.The CR＋PR＋SD rate of the experimental group increased to 80.0%（P〈0.05）. Conclusion： Chinese herbs have some effects on lung cancer because the level CEA mRNA gene reduce after treatment. CR＋PR rate and clinical benefit respones.

关 键 词：CEA MRNA 肺癌 肿瘤转移 中药 

分 类 号：R730.5[医药卫生—肿瘤]