文拉法辛与选择性5-羟色胺再摄取抑制剂治疗抑郁症引发失眠、焦虑、激越与躁狂的Meta分析  

Meta-analysis of differences on incidence of insomnia,anxiety,irritability,and manic episode induced by venlafaxine and SSRIs.

作　　者：金卫东[1] 陈炯[1] 马永春[1] 王鹤秋[1] 邢葆平[1] 童振华[1] 陈正昕[1] 王佩蓉[1] 

机构地区：[1]浙江省立同德医院,浙江省精神卫生中心,210012

出　　处：《精神医学杂志》2007年第3期129-131,共3页Journal of Psychiatry

基　　金：浙江省卫生厅医药科研基金资助项目(2006A017)

摘　　要：目的分析文拉法辛与选择性5-羟色胺再摄取抑制剂（SSRIs）治疗抑郁症引发失眠、焦虑、激越与躁狂的差异。方法应用循证医学的Meta分析，采用固定效应模型（fixed effects model，FEM）法对符合标准的26项对照研究文献进行评价。结果文拉法辛与SSRIs治疗抑郁症出现失眠（12.70%V12.55%）差异没有显著性（P〉0.05），但是焦虑（4.62%V13.08%）、激越（8.54%V4.8%）以及躁狂发作（5.21%V1.82%）的差异均有显著性（P〈0.05-0.01）），OR分别是0.31，2.15和2.98。结论在治疗抑郁症中，文拉法辛与SSRI均可引发失眠、焦虑、激越与躁狂发作，特别需要注意SSRI可能引发的焦虑和文拉法辛可能引发的激越与躁狂发作。Objective To compare the differences on incidence of insomnia, anxiety, irritability, and manic episode induced by venlafaxine and SSRIs. Methods A total of 26 standard articles published were analysed by fixed effects model, meta-analysis of evidence-based medicine（EBM）. Results No significant differences on incidence of insomnia（12.70 % V12.55 %） was found（P〉0.05）, but significant differences on incidence of anxiety（4.62%V13.08%）, irritability（8.54%V4.8%）, and manic episode （5.21%V1. 82%）induced by venlafaxine and SSRIs were found（P〈0.05-0.01）, Comprehensive OR were 0.31,2.15 and 2.98 respectively. Conclusion Attention should be put on anxiety during treatment with SSRIs, and irritability, manic episode during treatment with venlafaxine. At same time insomnia induced by venlafaxine and SSRIs also should be noticed.

关 键 词：文拉法辛 SSRIS 躁狂发作 循证医学 

分 类 号：R749.4[医药卫生—神经病学与精神病学]