肝硬化血清总胆汁酸检测的临床意义  

Clinical significance of serum TBA in patients with cirrhosis

作　　者：朱先女 陈卓鹏 

机构地区：[1]广东省粤北第二人民医院院部门诊,韶关512028 [2]广东省粤北第二人民医院内科,韶关512028

出　　处：《华北煤炭医学院学报》2008年第1期13-14,共2页Journal of North China Coal Medical College

摘　　要：①目的探讨肝硬化患者血清总胆汁酸(TBA)与肝纤维化标志物及其与Child-pugh分级的关系。②方法检测56例肝硬化患者的血清TBA、胆红素、凝血酶原时间、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、IV胶原(IV-C)及层黏蛋白(LN)。③结果随着Child-pugh分级的增加,血清HA、PCⅢ、IV-C、LN及TBA水平逐步增高,C级与A级比较均有显著性差异(P<0.01)。血清TBA与PCⅢ、IV-C及HA呈显著正相关(P<0.005;P<0.05;P<0.0005),但与LN相关不显著(P>0.05)。④结论血清TBA升高与肝纤维化及Child-pugh分级有密切关系,联合检测TBA与肝纤维化标志物,对判断肝硬化患者病情及预后有重要参考意义。Objective To stady the relationship among serum TBA, liver fibrosis marks aad Child -pugh grade in patients with cirrhosis. Methods The levels of senlm TBA,bilirubin, prothrombin time,HA,PCⅢ,Ⅳ - C and LN in 56 patients with cirrhosis were examined. Results As Child - pugh grade increased, the level of senlm HA, PCⅢ, Ⅳ - C, LN and TBA was increased gradually, there was significant difference between C grade and A grade（ P 〈 0.01 ）. Serum TBA was positively correlated with PCI- Ⅱ, Ⅳ- C and HA ,while it was no corralation with LN （ P 〉 0.05 ）. Conclusion Serum TBA increase was closely correlated with liver fibrosis and Child - pugh grade. It was important significance of TBA and liver fibrosis marks combination examination to estimate the state of an illness and prognosis of patients with liver cirrhosis.

关 键 词：肝硬化 总胆汁酸 肝纤维化标志物 CHILD-PUGH分级 

分 类 号：R575.2[医药卫生—消化系统]