DNA甲基化与鼻咽癌  

DNA methylation and nasopharyngeal carcinoma

作　　者：谭双香[1] 肖志强[1] 

机构地区：[1]中南大学湘雅医院卫生部肿瘤蛋白质组学重点实验室,长沙410078

出　　处：《国际肿瘤学杂志》2007年第12期904-907,共4页Journal of International Oncology

摘　　要：癌基因和抑癌基因表达失常是鼻咽癌发病的关键。鼻咽癌与细胞凋亡和细胞周期调控基因、细胞黏附分子编码基因、应激反应基因、DNA错配修复基因、维甲酸信号通路相关基因、Wnt信号通路相关基因以及RIZ1基因、DLC1基因、H19和COX-2基因等基因异常甲基化相关。Upset expression of oncogenes and anti-oncogenes plays a key role in development of nasopharyngeal carcinoma- Nasopharyngeal carcinoma is associated with abnormal methylation of genes involved cell apoptosis and cell cycle regulation, cellular adhesion molecule coding, stress reaction, DNA mismatch repair, ratinoic acid signal path, Wnt signal path. In addition, nasopharyngeal carcinoma is associated with abnormal methylation of other genes such as RIZ1 gene, DLCI gene, H19 gene and COX-2 gene.

关 键 词：DNA甲基化 鼻咽肿瘤 

分 类 号：R739.63[医药卫生—肿瘤]