MGMT和Survivin在乳腺癌中的表达及其临床意义(英文)  

Expression of MGMT and Survivin in Breast Cancer and Its Clinical Significance

作　　者：王发亮[1] 薄爱华[2] 芦广萍[2] 侯金超[1] 吴荣薇[1] 

机构地区：[1]河北北方学院大学生科协,河北张家口075000 [2]河北北方学院电镜室,河北张家口075000

出　　处：《河北北方学院学报（医学版）》2008年第1期27-31,共5页Journal of Hebei North University:Medical Edition

摘　　要：目的:研究MGMT和Survivin在乳腺癌中的表达及其临床意义。方法:福尔马林固定,石蜡包埋乳腺癌和腺瘤标本,采用SABC免疫组织化学方法检测MGMT和Survivin在这些组织中的表达。结果:MG-MT和Survivin在乳腺癌和乳腺腺瘤中的表达有显著性差异。MGMT在乳腺癌中的表达与患者的年龄、淋巴结转移有关,而Survivin仅与淋巴结转移有关。另外,MGMT和Survivin之间具有相关性(r=0.48,P<0.01)。结论:MGMT和Survivin的异常表达与乳腺癌的淋巴结转移有关;MGMT和Survivin可以作为判断乳腺癌发生和预后的重要指标;检测它们的表达可以指导临床上化疗方案的制定。Objective： To investigate the expression of MGMT and Survivin in breast cancer and its clinical significance. Methods：Specimens from breast adenoma and breast cancer were taken and had been For- malin-fixed, paraffin-embedded. With Strept Avidin-Biotin Complex（SABC） immunohistochemical technique, the expression of MGMT and Survivin in these specimens was examined. Results： It was found that there were significant differences between MGMT and Survivin in breast adenoma and breast cancer. The expression of MGMT was correlated with the patients＇age and lymph node metastasis,while the expression of Survivin was associated with lymph node metastasis only. Meanwhile,the expression of MGMT was correlated with that of Survivin（r=0.34,P〈0.01）. Conclusion： It was concluded that the abnormal expressions of MGMT and Survivin were associated with lymph node metastasis. They possibly could be useful indexes for the primary screening and the prognosis of breast cancer. The examination of them may have an important guiding significance in the chemotherapy strategy.

关 键 词：O^6-甲基鸟嘌呤-DNA-甲基转移酶 生存素 乳腺肿癌 

分 类 号：R737.9[医药卫生—肿瘤]