瘦素与乳腺癌的相关性及其致癌机理  

Relations carcinogenic mechanism between Leptin and breast cancer

作　　者：白庆阳[1] 谷俊朝[1] 侴丽鸿[2] 

机构地区：[1]首都医科大学附属北京友谊医院普外科,北京100050 [2]包钢第三职工医院特检科,包头014010

出　　处：《国际外科学杂志》2008年第1期37-40,共4页International Journal of Surgery

基　　金：首都医学发展科研基金（No.2005-2031）;首都医科大学基础-临床科研合作基金（No.12260133）

摘　　要：肥胖是乳腺癌的一个危险因素，瘦素是肥胖基因编码的蛋白产物，与肥胖密切相关，瘦素与乳腺癌有什么样的关系呢？本文就瘦素在乳腺癌体外细胞系、活体血清及组织中的表达及其相关性作了详细阐述，同时从瘦素与雌激素、瘦素与IGF1及LPR基因的多态性等方面对瘦素可能的作用机理进行概述。Obesity is a risk factor for breast cancer, leptin is the protein product of the obese gene enco- ding, Which is closely related to the obesity, what is the relationship between leptin and breast cancer？ In this paper, we discussed the expression of leptin in breast cancer cell lines serum and breast tissues;mecha- nism in the process have be outlined from the relationship of leptin and estrogen, leptin and IGF1, and the gene polymorphisms of LPR .

关 键 词：瘦素 乳腺癌 致癌机理 

分 类 号：R737[医药卫生—肿瘤]