AgNOR检测对鉴别结核性与癌性胸腔积液的诊断价值  

The diagnostic value of AgNOR in tuberculosis and malignant pleural effusion

作　　者：张秀琴[1] 王炳成 赵维川[1] 

机构地区：[1]承德医学院附属医院检验科,承德067000 [2]河北省隆化县医院检验科

出　　处：《陕西医学杂志》2008年第1期100-102,共3页Shaanxi Medical Journal

摘　　要：目的:研究核仁组成区嗜银蛋白(AgNOR)对结核性与癌性胸腔积液鉴别的诊断价值。方法:采用MPIAS-500多媒体病理图文分析系统定量测定80例胸腔积液(40例结核性积液和40例癌性积液)中脱落细胞的AgNOR颗粒10项参数,并对AgNOR形态进行观察分型。结果:癌性积液组AgNOR的10项参数测定指标均与良性组有显著性差异(P<0.01),并且癌性胸腔积液组癌细胞核内AgNOR颗粒以弥散型、聚集型和混合型为主,而结核性积液组细胞核内AgNOR颗粒以单一型为主。结论:胸腔积液AgNOR检测对结核性与癌性胸腔积液的鉴别诊断有重要价值。Objective： To study the value of argyophilic nuclear organizer regions （AgNOR） in differentiating tuberculosis from malignant pleural effusion. Methods： Eighty specimens of pleural effusion （40 cases of tuberculosis pleural effusion and 40 cases of malignant pleural effusion） were analyzed by silver staining method. Results： The AgNOR results of malignant pleural effusion were obviously higher than those in tuberculosis pleural effusion （P ~ 0. 01）. There were many dispersion, congregation and commix in the morphological study of AgNOR particles in malignant pleural effusion , but single form in tuberculosis pleural effusions, Conclusion： AgNOR technique, being a new effective method, has an important clinical value in diagnosis and differential diagnosis of tuberculosis and malignant pleural effusion .

关 键 词：鉴别诊断 核蛋白质类代谢 结核性胸腔积液 癌性胸腔积液 AGNOR检测 

分 类 号：R734[医药卫生—肿瘤]