当归超微粉直接压片工艺研究  

Study on the Direct Powder Compression Technique of Angelica Micropowder

作　　者：孙强[1] 何应[1] 

机构地区：[1]天津大学药物科学与技术学院,天津市300072

出　　处：《中国药房》2008年第3期183-185,共3页China Pharmacy

摘　　要：目的:研究当归超微粉直接压片成型的工艺。方法:采用混料均匀设计法,以片重差异、脆碎度为限制条件,以硬度、崩解度的综合评分为指标建立回归方程,求出综合最优解,对当归超微粉片处方进行优化。用DPS软件进行数据运算。结果:最佳处方为应用粉末直接压片法制备片剂,其硬度可达到75N,崩解时间为10.24min,且片面光滑无缺。结论:该工艺处方合理、成型性好,可为工业化生产提供理论依据。OBJECTIVE： To study the direct powder compression technology of Angelica micropowder. METHODS： The formula of Angelica micropowder was optimized by mixture uniform design with tablet weight variation and friability as re strictive conditions, and a regression equation was established based on the comprehensive grading on the hardness and disintegration to figure out the optimal solution. DPS software was applied in the calculation, RESULTS： Prepared by the direct powder compression technology, the optimal formula of Angelica micropowder was obtained as follows： the hardness of the optimized tablet could reach as high as 75 N and the disintegrating time was about 10.24 min, with smooth and intact surface. CONCLUSION： The technology is reasonable in formulation and satisfactory in molding, and it can serve as theoretical basis for the production of Angelica tablets.

关 键 词：当归超微粉 粉末直接压片 混料均匀设计 多指标综合评分法 

分 类 号：R283[医药卫生—中药学] R944[医药卫生—中医学]