胸腔积液中肿瘤标志物的水平与肺癌的诊断、组织学分型的关系  

The relationship between the levels of tumor markers and histological types in pleural effusion of the patients with lung cancer

作　　者：程田[1] 刘献华[1] 张清萍[1] 符本琪[1] 宋文忠[1] 

机构地区：[1]四川省人民医院核医学科,四川成都610072

出　　处：《四川医学》2008年第1期38-39,共2页Sichuan Medical Journal

摘　　要：目的探讨胸腔积液中CYFRA21-1、NSE、CEA和CA125的检测对肺癌的诊断价值以及与组织学分型的关系。方法采用电化学发光法和化学发光法分别检测187例肺癌,28例其他恶性肿瘤以及25例结核患者胸腔积液中CYFRA21-1、NSE和CEA、CA125的水平。结果肺癌组胸腔积液中CYFRA21-1、NSE、CEA和CA125水平明显高于其他恶性肿瘤组和结核组(P<0.01)。CYFRA21-1、NSE以及CEA的水平分别在肺鳞癌、小细胞肺癌以及肺腺癌中最高(P<0.01,P<0.01,P<0.05)。结论检测胸腔积液中CYFRA21-1、NSE、CEA和CA125水平对肺癌的鉴别诊断、组织学分型有重要价值。Objective To investigate the diagnostic value of detection of eytokeratin fragment 19（ CYFRA21-1 ）, neuron specific enolase （NSE）, carcinoembryonic antigen （CEA）, cancer antigen 125 （CA125）in pleural effusion caused by lung cancer, moreover, the relationship between the levels of these tumor markers and histological types. Methods CYFRA21-1, NSE were detected by electrochemi-luminescence immunoassay and CEA, CA125 were detected by chemiluminescence immunoassay in pleural effusion of 240 patients（187 lung cancer,28 other cancers and 25 tuberculosis）. Results The levels of CYFRA21- 1, NSE, CEA and CA125 in pleural effusion of lung cancer group were more higher than in other cancers group and tuberculosis group（ P 〈 0.01 ） .The levels of CYFRA21-1 in squamous cell carcinoma,NSE in small cell lung cancer（SCLC） and CEA in adenocarcinoma is the highest one respectively（ P 〈 0.01, 〈 0.01 and 〈 0.05 respectively）. However, the level of CA125 had no relationship with histological types. Conclusion The detection of CYFRA21-1,NSE,CEA and CA125 in pleural effusion have the value of the differential diagnosis to lung cancer and may be applied to assess histological types.

关 键 词：肺癌 胸腔积液 CYFRA21-1 NSE CEA CA125 组织学分型 

分 类 号：R734.2[医药卫生—肿瘤] R730.2[医药卫生—临床医学]