天津市部分高校在校生碘干预前后尿碘与膳食总摄碘量的关系  

Relationship of dietary iodine intakes and the urine iodine after iodine intervention in undergraduates in Tianjin

作　　者：王卓[1,2] 孙伟[1] 沈钧[3] 桑仲娜[1] 刘嘉玉[4] 吴蕴棠[1] 陈祖培[4] 张万起[1] 

机构地区：[1]天津医科大学公共卫生学院营养与食品卫生学教研室,300070 [2]天津市疾病预防控制中心 [3]天津医科大学卫生化学教研室 [4]天津医科大学内分泌研究所

出　　处：《中国地方病学杂志》2008年第1期87-89,共3页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金（30571564）;中国营养学会基金（200401）

摘　　要：目的了解碘营养干预前后人群尿碘水平的变化情况，探讨砷铈催化分光光度法所测定的尿碘与膳食总摄碘量间的关系。方法天津市161名大学生健康志愿者，随机分为7组．每组给予不同剂量的碘营养补充剂。补碘第0、2、4周采集一次空腹晨尿，采用砷铈催化分光光度法测定尿中含碘量，碱性苦味酸法测定尿肌酐：7日膳食记录法了解经食物摄入碘的情况。结果给予碘补充剂后。各剂量组尿碘水平均高于补碘前。差异有统计学意义（P〈0．01）；而第4周虽比第2周尿碘略有升高。但差异无统计学意义（P〉0．05）。肌酐校正的尿碘中位数为271．28μg／g Cr，尿碘排泄量中位数为324．54μg／d，膳食摄人碘量中位数为329．71μg／d，尿碘与膳食碘进行相关性分析，r=0．463（P〈0．01）。校正尿碘值比未校正尿碘值与膳食摄碘量的相关系数高（第2、4周校正前r值为0．583、0．593，校正后为0．708、0．733），补碘后比补碘前的校正尿碘值与膳食摄碘量的相关系数高。结论尿碘测定结果及膳食调查结果获得的机体总碘量基本一致。经肌酐校正的尿碘更能准确地反映膳食摄碘量，而且高碘摄人时两者关系更密切。Objective To explore the change of urine iodine after iodine intervention and to discuss the relationship between the urine iodine and the total dietary iodine intakes by arsenic-cerium catalysis spectrophotometry. Methods 161 healthy undergraduates in Tianjin were divided into 7 groups, each being administered with different iodine dosage. Their urinary iodine was determined by arsenic-cerium catalytic spectrophotometry, and urine creatinine by the method of alkaline picric acid. Their dietary information was documented for 7 days. Results After iodine intervention, the urinary iodine elevated, with a statistical significance （P 〈 0.01 ）; although it was higher in the 4^th week than in the 2^nd week, but there was no statistical significance （P 〉 0.05）. After urinary iodine was corrected by urine creatinine, the median of urine iodine was 271.28 μg/g Cr, the median of the urinary iodine excreted was 324.54 μg/d, the intake of iodine from diet was 329.71μg/d. The correlation of urinary iodine and dietary iodine intakes was performed, r = 0.463 （P 〈 0.01）. Correlation coefficient between urinary iodine and intake of dietary iodine（r - 0.708, 0.733 in the 2^nd and 4^th week） was higher when urinary iodine was corrected by urinary creatinine than that uncorrected （r = 0.583, 0.593 in the 2^nd and 4^th week）. Urinary iodine was better correlated with dietary iodine when iodine was supplied. Conclusions The result of urine iodine measured is similar to that of dietary investigation. Urinary iodine corrected by urine creatinine more exactly reflects the intake of dietary iodione, furthermore, the correlation is more close when high iodine is taken.

关 键 词：碘 膳食调查 人群监测 

分 类 号：R686[医药卫生—骨科学]