隐原性机化性肺炎和普通型间质性肺炎的临床和病理分析  

Comparative analysis of clinic and pathology of cryptogenic organizing pneumonia and conventional interstitial pneumonia

作　　者：甘泉涌[1] 易祥华[2] 褚海青[3] 张韵[2] 王彦丽[2] 

机构地区：[1]襄樊职业技术学院医学院医学基础教研室,湖北441021 [2]同济大学附属上海市肺科医院病理科 [3]同济大学附属上海市肺科医院呼吸病科

出　　处：《江苏医药》2008年第1期9-11,I0002,共4页Jiangsu Medical Journal

基　　金：上海市科学技术委员会科研基金资助项目(034119868)

摘　　要：目的探讨隐原性机化性肺炎(COP)和普通型间质性肺炎(UIP)的临床和病理特征以及鉴别诊断。方法选择经临床-影像-病理诊断的COP和UIP各17例,回顾性分析两组的临床、影像和病理特征、糖皮质激素治疗效果以及随访结果。结果UIP组显示更严重的肺功能异常。COP组和UIP组对糖皮质激素的有效率分别为76.5%(13/17)和17.6%(3/17)(P<0.01)。两组的痊愈、稳定、复发和进展、死亡例数分别为5,8,3,1和0,1,12,4例。结论与UIP相比,COP对糖皮质激素有较好的反应和预后。Objective To investigate the clinical and pathological features and differential diagnosis of cryptogenic organizing pneumonia（COP）and conventional interstitial pneumonia（UIP）. Methods A total of 34 patients diagnosed as idiopathic interstitial pneumonia by clinico-radiologicpathologic methods were divided into COP group（17 cases） and UIP group（17 cases）. The clinical, radiologic and pathologic features, therapeutic efficacies of glucocorticosteroids and follow-up results were retrospectively analyzed. Results UIP group demonstrated more severe abnormalities in lung function than COP group. The effective ratio of glucocorticosteroid therapy in COP group was 76.5 %, which was significantly higher than that（17.6 %） in UIP group（P〈0.01）. The case number of cured, stable, relapse and progress, death in COP and UIP group were 5,8,3,1 and 0,1,12,4, respectively. Conclusion Compared with UIP, COP has a better response to glucocorticosteroid therapy and prognosis.

关 键 词：隐原性机化性肺炎 普通型间质性肺炎 诊断 预后 

分 类 号：R734[医药卫生—肿瘤]