脑膜瘤中HIF-1α、VEGF和MMP-9的表达及其意义  

Expression and significance of HIF-1α,VEGF and MMP-9 in meningiomas

作　　者：蒋寅[1] 赵三虎[1] 朱晓江[1] 

机构地区：[1]上海市第一人民医院神经外科,200080

出　　处：《江苏医药》2008年第1期34-36,共3页Jiangsu Medical Journal

摘　　要：目的探讨脑膜瘤中低氧诱导因子1α(HIF-1α)、血管内皮生长因子(VEGF)和基质金属蛋白酶9(MMP-9)表达与脑膜瘤组织学分级、复发的关系。方法采用免疫组化方法检测脑膜瘤标本中HIF-1α、VEGF和MMP-9表达情况,分析它们相互间以及与脑膜瘤组织学分级、复发的关系。结果(1)52例脑膜瘤标本中HIF-1α、VEGF和MMP-9的阳性表达率分别为78.8%、84.6%和73.1%;表达强度均与脑膜瘤的病理级别呈正相关(rs=0.499、0.448、0.583,P<0.01);(2)VEGF表达强度与HIF-1α的表达强度呈正相关(rs=0.714,P<0.01),MMP-9表达强度与HIF-1α、VEGF的表达强度无关(rs=-0.0066,rs=-0.095,P>0.05);(3)52例脑膜瘤中有7例复发,复发率为13.5%;脑膜瘤复发与性别、发病年龄不相关(P>0.05);而与病理分级以及HIF-1α、VEGF和MMP-9表达强度相关(P<0.01)。结论HIF-1α、VEGF和MMP-9表达与脑膜瘤分级及术后复发密切相关。HIF-1α可有诱导血管生成的作用。Objective To investigate the relationship between the expression of hypoxiainducible factor-1α （HIF-1α）, vascular endothelial growth factor （VEGF） and matrix metalloproteinase-9 （MMP-9） and the pathological grades and recurrence of meningioma. Methods The expression of HIF-1α, VEGF and MMP-9 was detected using immunohistochemical method in 52 specimens of meningiomas. The relationship between the expressions and the pathological grades and recurrence of meningioma was statistically analyzed. Results In 52 specimens of meningiomas, the positive rates of the expression of HIF-1α, VEGF and MMP-9 were 78.8%, 84. 6% and 73.1%, respeotively. There was a positive correlation between HIF-1α, VEGF, MMP-9 expression and pathological grade （rs=0. 499, 0. 448, 0. 583, P〈0. 01）. There was a positive correlation between VEGF expression and HIF-1α expression （rs = 0. 714, P〈 0. 01）. The expression of HIF-1α and VEGF had no correlation with that of MMP-9（rs =-0. 0066,rs =-0. 095, P〉0. 05）. Of 52 cases, the recurrence was found in 7 cases （13.5 % ）. The recurrence of meningioma had no relationship with sex and age, but was correlated to the pathological grades and the expression of HIF-1α, VEGF and MMP-9. Conclusion The expression of HIF-1α, VEGF and MMP-9 is closely correlated with pathological grade and postoperative recurrence of meningioma. HIF-1α may have an effect of inducing angiogenesis.

关 键 词：脑膜瘤 低氧诱导因子1Α 血管内皮生长因子 基质金属蛋白酶9 

分 类 号：R739[医药卫生—肿瘤]