吲哚胺2,3双加氧酶在肿瘤局部免疫耐受中的作用  

Indoleamine2,3-dioxygenase and tolerance to tumors

作　　者：谢启超[1] 王玲俐[1] 朱波[1] 陈正堂[1] 

机构地区：[1]第三军医大学附属新桥医院解放军肿瘤研究所,重庆400037

出　　处：《医学研究生学报》2008年第1期73-75,共3页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助项目(批准号:30300150);第三军医大学青年基金资助项目(批准号:2006D143)

摘　　要：吲哚胺2,3双加氧酶(IDO)是人体内肝外色氨酸代谢限速酶,最近研究表明,在肿瘤微环境内产生免疫耐受的机制中,多种细胞成分通过高表达IDO,导致肿瘤局部色氨酸代谢异常及调节性T细胞形成,对T细胞的增殖、分化和活性产生影响,进而介导肿瘤局部的T细胞免疫耐受,在恶性肿瘤的发生、发展和转移过程中发挥了重要作用。现就吲哚胺2,3双加氧酶在肿瘤局部免疫耐受中的作用作一综述。Indoleamine 2, 3-dioxygenase（IDO） is the crucial rate-limiting enzyme of tryptophan outside the liver in the body and is considered as an immune defense mechanism in tumor microenvironment. IDO is expressed in a number of ceils including cancer cell, dendretic cell and so on. In tumor microen-vironment, the overexpression of IDO can lead to the exhaustion of tryptophan and induce the proliferation of regulatory ceils, which can prevent the proliferation, diffenentiation and activity of T ceils and result in the immune tolerance to tumors.

关 键 词：吲哚胺2 3双加氧酶 免疫耐受 肿瘤微环境 T细胞 

分 类 号：R730.5[医药卫生—肿瘤]