LPT、阴道镜检查结合C-erbB2、nm23-H1表达早期诊断宫颈癌的临床研究  

Study on significance of LPT,colposcopy and expression of C-erbB2 and nm23-H1 in early diagnosis of cervical carcinomal

作　　者：杜亚丽[1] 原继荣[1] 肖兵[1] 

机构地区：[1]哈尔滨医科大学第二附属医院,黑龙江哈尔滨150086

出　　处：《中国优生与遗传杂志》2008年第2期62-64,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨LPT、阴道镜检查及C-erbB2、nm23-H1表达对宫颈癌(IC)早期诊断的意义。方法对392例可疑患者行LPT、阴道镜检查及定位活检;采用免疫组化法对检出的32例IC、70例宫颈上皮内瘤样变(CIN)和10例正常组织(NE)行C-erbB2、nm23-H1检测。结果140例LPT异常,占35.71%;89例阴道镜检查异常,占22.70%;102例C INⅠ以上,占26.02%。CINⅠ以上组织中C-erbB2和nm23-H1表达依次增高,与NE比较有显著差异(P(0.05)。结论LPT、阴道镜检查加定位活检结合C-erbB2及nm23-H1表达可早期诊断IC。Objective:To detect the significance of LPT,colposcopy and expression of C-erbB2 and nm23-H1 in early diagnosis of cervical carcinoma.Methods:392 cases with cervix erosion were examined by LPT,colposcopy and biopsy;among them 32 cases with invasive carcinoma(IC),70 cases with cervical intraepithelial neoplasia(CIN),C-erbB2 and nm23-H1 were examined the expression by immunohistochemical staining(including 10 cases of normal cervix tissues).Results: There were 140 cases(35.71%) and 89 cases(22.70%) showed abnormal in the check of LPT and colposcopy;102 cases(26.02%)showed CINⅠ.Expression of C-erbB2 and nm23-H1 were increased significantly from NE,CIN and invasive cervical carcinoma(P﹤0.05).Conclusion: The check of LPT,colposcopy and the expression of C-erbB2 and nm23-H1 play an important role in early diagnosis of cervical carcinoma.

关 键 词：宫颈癌 LPT 阴道镜 C—erbB2 NM23-H1 

分 类 号：R737.33[医药卫生—肿瘤]