肝靶向微粒给药系统的研究进展  

Research Progress of Liver Targeting Particles Drug Delivery Systems

作　　者：孙洁胤[1] 周芝芳[1] 刘放[1] 

机构地区：[1]浙江省医学科学院,杭州310013

出　　处：《中国现代应用药学》2007年第6期457-461,共5页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的对近年来微粒给药系统在肝靶向治疗的研究进展做一综述。方法根据国内外文献资料进行整理归纳。结果纳米粒、微球、脂质体及微乳等微粒系统具有被动靶向于肝的趋势,利用肝细胞表面某些受体则可特异性靶向于肝达到主动靶向作用。结论微粒给药系统在肝靶向治疗领域具有重要意义。OBJECTIVE To introduce liver targeting particles drug delivery systems and its research progress in recent years. METHODS Settle and consult literature both in domestic and foreign, the development of liver targeting were reviewed. RESULTS Drug delivery systems via particles such as nanoparticles, microparticles, liposome and microemulsion have a tendency to liver by the way of swallowed by kupfferg cell. Depend on receptor located on the liver cell, modified particles can have liver targeting characteristic. CONCLUSION Particles drug delivery systems which have liver targeting characteristic will have greater use in the field of target therapy.

关 键 词：肝靶向 微粒给药系统 纳米粒 微球 脂质体 微乳 

分 类 号：R943.42[医药卫生—药剂学]