食管癌DNA倍体及增殖活性与病理特征的关系  

Relationship between DNA Content,Proliferative Activity and Pathological Feature in Oesophagus Carcinoma

作　　者：沈玉光[1] 张瑞祥[1] 巴玉峰[1] 赵婷茹[2] 许金良[1] 

机构地区：[1]河南省肿瘤医院胸外科,郑州4500081 [2]河南省肿瘤医院病理科,郑州4500081

出　　处：《肿瘤防治研究》2008年第1期33-35,共3页Cancer Research on Prevention and Treatment

摘　　要：目的探讨食管癌组织DNA含量(DI)、合成期细胞比例(SPF)、增殖指数(PI)与临床病理特征间的关系。方法应用流式细胞仪测定98例新鲜食管癌组织细胞的DI、SPF、PI值,研究其和食管癌临床病理的关系。结果(1)异倍体率、DI、SPF、PI等指标在以患者性别、肿瘤大体类型、分化程度、TNM分期等病理特征为分组对象的各组间没有发现差异有统计学意义;(2)食管组织淋巴结阳性组的SPF明显大于淋巴结阴性组(P=0.03)。结论(1)食管组织一旦癌变后其细胞DNA的改变和临床分期等病理指标没有明显关系;(2)食管癌淋巴结转移和食管癌组织合成期细胞比例(SPF)有关。Objective To investigates the relationship between DNA, cell cycle analysis and the pathological feature in squamous cell carcinoma （SCC） of the esophagus. Methods Flow cytometry was used to measure DNA ploidy and synthesis-phase fraction （SPF） of the resected esophageal tissues from 98 patients with squamous cell carcinoma （SCC） of the esophagus. Results DNA aneuploidy was present in 66 （67. 3%） of the 98 patients. There were no significant differences in DNA content and the clinicopatho- logical features such as sex, pathological type, differentiation, TNM stage, lymph node involvement. However, we detected that the lymph node positive group had a significant higher SPF than that of the negtive group （P = 0.03）. Conclusion Although the DNA index （DI） in esophageal carcinoma has little clinical significance, the synthesis-phase fraction （SPF） can help to evaluate the involvement of lymph node.

关 键 词：食管癌 流式细胞术 DNA倍体 增殖活性 病理 

分 类 号：R735.1[医药卫生—肿瘤]