坦度螺酮与氯硝西泮治疗广泛性焦虑症的对照研究  

A comparative study of tandospirone versus clonazepam in the treatment of generalized anxiety disorder

作　　者：陶用富[1] 赵智慧[1] 周豪[1] 杨东芳[1] 郑兴元[1] 赵建容[1] 丁佑萍[1] 

机构地区：[1]四川省绵阳市精神卫生中心,621000

出　　处：《精神医学杂志》2008年第1期27-28,共2页Journal of Psychiatry

摘　　要：目的了解坦度螺酮对广泛性焦虑症的治疗效果及不良反应。方法将符合CCMD-3广泛性焦虑症诊断标准的82例患者随机分为坦度螺酮组(41例)和氯硝西泮组(41例),均治疗6周,采用汉密顿焦虑量表(HAMA)和临床疗效总体量表(CGI)以及不良反应量表(TESS)评定疗效和不良反应。结果坦度螺酮和氯硝西泮对广泛性焦虑症均有显著疗效,两组间差异无显著性(P>0.05)。坦度螺酮组不良反应明显小于氯硝西泮组(P<0.01)。结论坦度螺酮治疗广泛性焦虑症安全有效,不良反应小。Objective The aim of this study was to evaluate the therapeutic effect and side effects of tandospirone for treating the patients with generalized anxiety disorder. Methods A total of 82 patients meeting the criteria of CCMD-3 for generalized anxiety disorder were randomly assigned to tandospirone group（n=41）or clonazepam group（n=41） for 6 weeks of treatment. The efficacy and side effects were assessed with HAMA,CGI and TESS. Results Both drugs had marked efficacy in the treatment of generalized anxiety disorder, and there bad no significant difference between two groups. Tandospirone had significantly fewer side effects than clonazepam. Conclusion Tandospirone is safe and effective with slight side effects for treating patients with generalized anxiety disorder.

关 键 词：广泛性焦虑症 坦度螺酮 氯硝西泮 

分 类 号：R749.72[医药卫生—神经病学与精神病学]