无抽搐电痉挛治疗紧张型精神分裂症的对照研究  

A comparative study of modified electroconvulsive therapy for catatonic schizophrenia

作　　者：刘同洲[1] 王善信[1] 王斌[1] 赵贵芳[1] 王丽萍[1] 张爱贞[1] 王旸[1] 

机构地区：[1]山东省精神卫生中心,济南250014

出　　处：《精神医学杂志》2008年第1期32-34,共3页Journal of Psychiatry

摘　　要：目的探讨无抽搐电痉挛治疗紧张型精神分裂症的疗效及安全性。方法采用入院顺序分层随机法,将81例紧张型精神分裂症患者分为研究组和对照组,共观察4周,在治疗前及治疗第1周末、第2周末、第4周末采用简明精神病评定量表(BPRS)、住院患者观察量表(NOSIE)、副反应量表(TESS)评定疗效及不良反应。结果治疗第1周末,研究组BPRS总分及各因子分较治疗前均有显著性改善(P<0.05),NOSIE的总分及各因子分较治疗前也有显著性改善(P<0.05),而对照组均无显著性改善。治疗第4周末,研究组和对照组的BPRS和NOSIE的总分及各因子分较治疗前均有显著性变化(P<0.05),但与对照组相比,研究组的BPRS和NOSIE的总分及各因子分均有显著性差异(P<0.05)。研究组未出现严重不良反应。结论无抽搐电痉挛治疗紧张型精神分裂症是快速、有效、安全的首选方法之一。Objective To explore the efficacy and side effects of modified electroconvulsive therapy （MECT） in the treatment of catatonic schizophrenia. Methods A total of 81 patients with catatonic schizophrenia were randomly divided into study group with MECT and control group with risperidone for treatment of 4 weeks. They were assessed and analysed contrastively using Brief Psychiatrc Rating Scale （BPRS） , Nurses Observation Scale （NOSIE） and Treatment Emergent Side Effect Scale （TESS） . Results In the 1st weekend, the total and factor scores of BPRS and NOSIE in study group were significantly lower than before treatment（P〈0. 05） and there was no difference in control group（P〈0.05）. In the 4th weekend, there were significant improvement of BPRS and NOSIE both in study group and control group（P〈0.05）. But the total and factors scores of BPRS and NOSIE had significant differences between study group and control group（P〈0. 05）. No severe side effects was found in study group. Covlclusion MECT is effective for treating patients with catatonic schizophrenia without severe side effects.

关 键 词：无抽搐电痉挛治疗 紧张型精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]