促红细胞生成素与炎性细胞因子在脑瘫发病中的作用  

Influence of Erythropoietin and Inflammatory Cytokines on Pathogenesis of Cerebral Palsy

作　　者：陶维元[1] 文芳[2] 姚汉云[1] 孙杨[1] 

机构地区：[1]武汉大学人民医院神经内科,湖北武汉市430060 [2]武汉大学人民医院神经精神病研究所,湖北武汉市430060

出　　处：《中国康复理论与实践》2008年第1期62-64,共3页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨脑保护因子促红细胞生成素(EPO)与免疫炎性细胞因子在脑瘫发病中的作用。方法检测31例脑瘫患儿(脑瘫组)和20名健康儿童(脑瘫对照组)及37例脑瘫高危因素新生儿(新生儿病例组)和20名正常新生儿(新生儿对照组)的血清EPO、肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6水平。结果新生儿病例组血清EPO水平明显高于新生儿对照组和脑瘫组(P<0.01),脑瘫组血清EPO水平与脑瘫对照组比较无显著性差异(P>0.05);新生儿病例组血清TNF-α和IL-6水平明显高于新生儿对照组(P<0.01);脑瘫组血清TNF-α和IL-6水平明显高于脑瘫对照组(P<0.01),脑瘫组血清TNF-α水平高于新生儿病例组(P<0.05),但两者间IL-6水平无显著性差异(P>0.05)。结论炎性细胞因子介导的脑破坏作用在与EPO的神经保护作用的抗衡中占据优势,促进或导致脑瘫的发生。Objective To investigate the effect of erythropoietin （EPO） as a brain-protective factor and inflammatory eytokines in the pathogenesis of cerebral palsy （CP）. Methods Serum samples from 31 CP patients, 37 neonates with CP risk factors such as hypoxic-ischemic injury and/or perinatal infection, and 20 controls of neonates or children were obtained respectively. EPO, tumor necrosis factor （TNF） -α and interleukin （IL） 6 levels were measured with the enzyme-linked immunosorbent assay double sandwich method （ABC-ELISA）. Results The serum EPO level of neonatal patients was higher than that of controls or CP group （P〈0. 01）, but there was no significant difference between CP group and controls. The serum TNF-α and IL-6 levels of CP and neonatal patients were higher than that in controls （P〈0.01）. The serum TNF-α level of CP group was higher than that of neonatal patients （P〈 0.05）. There was no significant difference between CP group and neonatal patients in serum IL-6 level. Conclusion The inflammatory responses mediated by proinflammatory cytokines may play a role in the pathogenesis of cerebral palsy.

关 键 词：脑性瘫痪 促红细胞生成素 炎性细胞因子 肿瘤坏死因子(TNF) 白细胞介素(IL) 免疫-神经-内分泌网络 

分 类 号：R742.3[医药卫生—神经病学与精神病学]