肝硬化患者胃液腹水胃动素水平测定的临床意义  

Determination and Significance of Motilin in Gastric Juice and Ascites in Patients with Liver Cirrhosis

作　　者：林其信[1] 陈为民[1] 王国平[1] 王小众 

机构地区：[1]福建医科大学附属协和医院,350001 [2]福建省消化研究室

出　　处：《中西医结合肝病杂志》1997年第2期71-73,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨胃液中胃动素的存在,腹水及血浆胃动素测定对肝硬化患者的临床意义。方法:以非平衡放射免疫法对45例肝硬化失代偿期患者进行胃液、腹水及血浆胃动素的检测。结果:胃液与腹水胃动素分别为246.22±50.34及395.32±54.22,与血浆胃动素水平、总胆红素、血肌酐及腹水量均呈正相关(各P<0.01);与血清白蛋白呈负相关(P<0.05)。按Child分级,C级组胃液、腹水胃动素较A、B级显著升高(P<0.01),提示胃液、腹水胃动素的高低与肝功能状况呈显著正相关。结论:胃液中不但存在胃动素,而且与腹水、血浆胃动素同步显著升高,此胃动素水平,对肝硬化的诊断具一定参考价值。Aim:In order to determine the level of motilin in gastric juice and to approach the clinical significance of motilin in gastric juice, ascites and serum in cirrhosis. Methods: The level of motilin in gastric juice, ascites and serum were measured by radioimmunoassay in 45 Patients with liver cirrhosis. Results:Motilin level in gastric juice (246. 22±50. 34) and ascites (295.32±54.22) have the positive relativities compared with the serum level, total bilirubin, serum creati-nine and the amount of ascites (each P<0. 01) and has a negative relativity compared with serum albumin (P<0. 05). According to the Child grades, the level of motilin in gastric juice and ascites with C grade patient were significanty higher than those of A grade and B grade (P<0.01). The results suggested that the level of motilin in gastric juice and ascites have the positive relativities compared with the state of liver function. Conclusion: Gastric juice not only contained the motilin, the level of motilin also consistent with those of ascites and serum. We concluded that the level of motilin has a certain reference value in the diagnosis of liver cirrhosis.

关 键 词：胃动素 肝硬变 诊断 

分 类 号：R575.204[医药卫生—消化系统]