Application of EEG multipole model in the diagnosis of Alzheimer's disease  

作　　者：Baikun Wan Longlong Cheng Xia Hu Dong Ming 

机构地区：[1]Department of Biomedical Engineering ＆ Scientific Instruments, Tianjin University, Tianjin 300072, China

出　　处：《Progress in Natural Science:Materials International》2008年第1期51-57,共7页自然科学进展·国际材料（英文版）

基　　金：This work was supported by National Natural Science Foundation of China(Grant Nos.60471028,60501005);Natural Science Foundation of Tianjin(Grant No.993607511).

摘　　要：In order to find the electroencephalogram (EEG) characteristic parameters typical of Alzheimer’s disease (AD) and explore an effec- tive diagnostic method, a new mobile current multipole model was proposed to simulate the AD patient’s cortical dipole source activities. The indicators of goodness of fit (GOF) and DtononD (DD) were calculated from EEG samples to evaluate the performance of this model. Relevant results showed that this multipole model with higher GOF values and larger DD change well fitted the pathological elec- trical activities of cortical neurons aroused by AD’s extended sulcus and gyrus in the cerebral cortex. Meanwhile, the products of DD mean & standard variance were found in a clear linear correlation with the diagnostic data of mini-mental state examination (MMSE) used in AD clinics. Furthermore, by tracing this multipole model’s indicators in typical patients and contrasting with the functional mag- netic resonance image (fMRI) as AD progressed, we suggested that the DD index may be suitable for monitoring the AD developments as a new diagnostic parameter.In order to find the electroencephalogram （EEG） characteristic parameters typical of Alzheimer＇s disease （AD） and explore an effective diagnostic method, a new mobile current multipole model was proposed to simulate the AD patient＇s cortical dipole source activities. The indicators of goodness of fit （GOF） and DtononD （DD） were calculated from EEG samples to evaluate the performance of this model. Relevant results showed that this multipole model with higher GOFvalues and larger DD change well fitted the pathological electrical activities of cortical neurons aroused by AD＇s extended sulcus and gyrus in the cerebral cortex. Meanwhile, the products of DD mean ＆ standard variance were found in a clear linear correlation with the diagnostic data of mini-mental state examination （MMSE） used in AD clinics. Furthermore, by tracing this multipole model＇s indicators in typical patients and contrasting with the functional magnetic resonance image （fMRI） as AD progressed, we suggested that the DD index may be suitable for monitoring the AD developments as a new diagnostic parameter.

关 键 词：Alzheimer＇s disease （AD） Electroencephalogram （EEG） Multipole model Goodness of fit （GOF） DtononD （DD） 

分 类 号：R742[医药卫生—神经病学与精神病学]