表面陶瓷化钛种植体与骨组织结合的界面表征及机制探讨  

Interface characteristics and mechanism analysis of osteointergration between bone tissues and surface porcelainized titanium implants

作　　者：马威[1] 刘宝林[1] 李德华[1] 魏建华[1] 

机构地区：[1]西安第四军医大学口腔医院种植科,710032

出　　处：《实用口腔医学杂志》2008年第1期17-20,共4页Journal of Practical Stomatology

摘　　要：目的:通过对种植体-骨组织界面表征的研究,评价和分析新型表面陶瓷化钛种植体(Bio-Tiimplant)的骨结合情况及机制。方法:制作犬下颌牙列部分缺损模型,设计制作相应的钛种植体,经过表面陶瓷化处理后,植入犬下颌骨,分别于3、6、12周处死动物,利用SEM对种植体表面矿物质沉积情况进行观察,同时分析其元素组成,对种植体-骨组织整体标本纵向界面进行元素线性扫描分析。采用未经表面处理的相同类型纯钛种植体作为对照。结果:Bio-Ti种植体周围新生类骨组织在3周时已有较多沉积,且与种植体结合较牢固,对少部分骨组织脱落处进行电镜观察及元素分析,种植体表面结构发生改建并且Ca、P含量明显上升,微孔内及周围可以看到颗粒状类骨质沉积物。线扫描及面扫描结果显示,从骨组织过渡到种植体的微观区域的Ca、P元素并未发生突变,提示两者之间磷酸钙成分的互相渗透与结合。结论:新型Bio-Ti表面陶瓷化纯钛种植体可以诱导体内类骨质早期沉积,与骨组织发生紧密结合,并显著缩短骨结合时间。Objective.To evaluate osteointegration condition and mechanism of surface porcelainized titanium implants （Bio-Ti implant） by studying the characteristics of implant-bone interface. Methods： Edentulous mandible models of dogs were established. Pure titanium implants were designed for in vivo experiments. Bio-Ti implants were installed in clogs＇mandible. All animals were sacrificed in 3, 6, 12 weeks respectively. Osteoid deposition on implants surface was observed and analyzed by SEM and EDX. Bone-implant interface of holistic specimen was analyzed by element linear scanning. All procedures were under the control of pure titanium implants. Results： Relatively great quantity of osteoid deposition could be found around Bio-Ti implants in 3 weeks, with tight combination with implants. Bio-Ti implant surface was found to have been reconstructed, Ca and P content markedly increased in partial exposed implant surface by SEM element analysis, with osteoid granules deposited inside micropores. Linear and planar scanning results showed no component breaks in the area along from bone tissue to implant, which suggested mutual infiltration and integration between implants and bone tissues. Conclusion： Bio-Ti implants can induce early osteoid deposition in vivo and chemically combine with bone tissues, within the period of markedly shortened osteointegration duration.

关 键 词：钛 牙种植体 陶瓷 骨结合 界面 

分 类 号：R783.1[医药卫生—口腔医学]