伽玛刀治疗垂体泌乳素瘤所致不孕症(附38例分析)  

Gamma knife radiosurgery for infertility caused by pituitary prolactinoma

作　　者：黄敏仪[1] 邓印辉[1] 梁舜尧[1] 李凯[1] 

机构地区：[1]广州医学院第二附属医院广州伽玛刀治疗研究中心,广东广州510260

出　　处：《中国微侵袭神经外科杂志》2008年第1期15-16,共2页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的探讨伽玛刀对垂体泌乳素瘤所致不孕症的治疗效果。方法对38例经伽玛刀治疗的垂体泌乳素瘤致不孕的育龄女性进行排卵情况追踪。均为已服用溴隐亭治疗的病人。结果伽玛刀治疗后,成功怀孕26例(73%)。内分泌复查显示:血清泌乳素(PRL)下降,卵泡刺激素(FSH)、黄体生成素(LH)升高。结论当口服溴隐亭治疗育龄妇女垂体腺瘤后,仍未能成功怀孕,或垂体瘤进行性增大者,应首选伽玛刀治疗;伽玛刀治疗能改善内分泌平衡,增加受孕机会。Objective To investigate therapeutic effect of Gamma knife radiosurgery for infertility caused by pituitary prolactinoma. Methods The ovulatory status of 38 reproductive age women with infertility-related to treatment of pituitary prolactinoma with Gamma knife were followed up, all of whom had received bromocriptine treatment. Results Twenty-six patients （73%） became pregnant after the treatment. Endocrine evaluation revealed a decreased prolactin （PRL） and increased follicle-stimulating hormone （FSH） and luteinizing hormone （LH）. Conclusion Gamma knife radiosurgery can improve the endocrine balance and increase chance of pregnancy and would be the first choice for the patients failed to pregnancy after oral administration ofbromocriptine and patients with progressive enlargement of prolactinoma.

关 键 词：催乳素瘤 不育 女性 放射外科手术 

分 类 号：R736.4[医药卫生—肿瘤] R815.2[医药卫生—临床医学]