乳腺癌前哨淋巴结的傅立叶变换红外光谱特征  

Sentinel lymph node's FT-IR character of breast cancer

作　　者：王健生[1] 段小艺[1] 石景森[1] 徐怡庄[2] 张莉[2] 吴瑾光[2] 

机构地区：[1]西安交通大学第一医院外科,陕西西安710061 [2]北京大学化学分子工程学院,北京100871

出　　处：《现代肿瘤医学》2008年第2期212-213,共2页Journal of Modern Oncology

基　　金：陕西省科技攻关项目(编号:37930160)

摘　　要：目的:探讨傅立叶变换红外光谱(FT-IR)技术用于判断乳腺癌前哨淋巴结转移与否的临床价值。方法:应用FT-IR、显微FT-IR、常规冰冻和免疫组化方法对13枚前哨淋巴结进行检测分析。结果:常规冰冻检查13枚前哨淋巴结有转移6枚,无转移7枚,术后常规石蜡切片结果与冰冻相同。免疫组化检测2枚中有微转移灶。FT-IR图显示有转移和无转移的淋巴结在吸收强度上存在差异,有转移在1740cm-1附近的吸收减弱。结论:FT-IR可以对乳腺癌前哨淋巴结有无转移做出判断。Objective：To observe the clinical value of fourier transform mid - infrared spectroscopy（ FT - IR） in detection of sentinel lymph node＇s（SLN） metastases. Methods： FT - IR, micFT - IR, Frozen sectioning and immunohistochemistry examinations were used in detecting the metastases of 13 SLN. Results： Cancer metastases were found in six of thirteen SLN by frozen sectioning, which was confirmed by hematoxyllin - eosin （H＆E） staining. Two SLN were found positive by immunohistochemistry which were negative by frozen sectioning. Differences of FT - IR absorption were found between the metastases and normal SLN, the typical difference was a weaker absorption at 1740cm^-1. Conclusion： FT- IR could detect the metastases of SLN.

关 键 词：乳腺癌 前哨淋巴结 傅立叶变换红外光谱 

分 类 号：R737.9[医药卫生—肿瘤]