Ang-2和ER在乳腺癌中的表达及其临床意义  

The expression of Ang-2 and ER in breast cancer and their clinical significance

作　　者：朱玉平[1] 王发亮[1] 薄爱华[2] 吴力娟[1] 张丽丽[1] 周宁[1] 

机构地区：[1]河北北方学院大学生科协,河北张家口075029 [2]河北北方学院实验中心,河北张家口075029

出　　处：《现代肿瘤医学》2008年第2期216-217,共2页Journal of Modern Oncology

基　　金：河北省科技厅科研项目(编号:03276117)

摘　　要：目的:研究乳腺癌组织中血管生成素-2(angiopoietin-2,Ang-2)和雌激素受体(estrogen receptor,ER)的表达及其临床意义。方法:采用免疫组织化学SABC法,检测87例乳腺癌组织中Ang-2及ER的表达情况。结果:乳腺癌中Ang-2的阳性率为68.97%(60/87),ER的阳性率为71.26%(62/87),二者表达呈低度正相关,(P<0.05)。Ang-2及ER在有淋巴结转移组中的阳性率明显高于无淋巴结转移组(P<0.05),Ang-2在浸润型乳腺癌组织中的表达明显高于非浸润型组(P<0.05);ER在乳腺癌组织中的表达与乳腺癌患者的年龄和是否有淋巴结转移有关(P<0.05)。结论:Ang-2可促进癌细胞的浸润;ER的阳性表达是预后的良好指标;Ang-2和ER在乳腺癌组织中表达的相关性不明显。Objective：To investigate the expression of Ang -2 and ER in breast cancer and their clinical significance. Methods：The expressions of Ang -2 and ER in the 87 specimens of breast cancer were examined by SABC immunohistochemical method . Results： The positive rate of Ang -2 was 68.97% （60/87）, and the positive rate of ER 71.26% （62/87） in human breast cancer, the positive expression of Ang -2 correlated positively with that of ER （ P 〈 0.05 ）. The positive rate of Ang - 2 and ER in lymphnode metastasis group was higher than that in the group without lymphnode metastasis （ P 〈 0.05 ）, the express of Ang - 2 in breast cancer was related with infiltration of cancer cell （ P 〈 0.05 ）, while the expression of ER was related with the ages of patients （ P 〈 0.05 ）. Conclusion： Ang -2 could help the invasion of cancer cell;The positive expression of ER in human breast cancer is an index of the good condition of the patients in the future;The expression of Ang-2 is not correlated positively with that of ER in human breast cancer.

关 键 词：乳腺癌 血管生成素-2 雌激素受体 免疫组织化学方法 

分 类 号：R737.9[医药卫生—肿瘤]