无症状性膀胱副神经节瘤1例报道并文献复习  

Paraganglioma of the urinary bladder without typical symptom:a case report and review of literature

作　　者：巩丽[1] 赵建业[1] 刘雪萍[1] 胡琴[1] 韩秀娟[1] 朱少君[1] 张伟[1] 

机构地区：[1]第四军医大学唐都医院病理科,陕西西安710038

出　　处：《现代肿瘤医学》2008年第2期248-250,共3页Journal of Modern Oncology

摘　　要：目的:讨论膀胱副神经节瘤的临床病理学特征和鉴别诊断。方法:报道1例无症状性膀胱副神经节瘤,对其进行光镜观察和免疫组化染色,同时回顾和总结国内外有关文献。结果:国内报道该肿瘤多发生于女性,而国外却多见于男性。排尿困难以及血尿和间歇性高血压是最常见的的临床症状,同时可伴发儿茶酚胺升高引起的头痛、视力模糊、心悸和脸红等症状。组织学特征与发生于性腺的副神经节瘤相似。免疫组化染色表达CgA,Syn,Vimentin,S-100蛋白和NSE。结论:膀胱副神经节瘤是一种罕见的肿瘤,在进行外科一系列诊疗过程前,必须要经过全面的观察。由于该肿瘤常浸润膀胱壁肌层,临床上一般对其进行部分膀胱壁的切除。准确的诊断仍然依靠临床症状、病理学特征以及免疫组化三方面的结合。Objective：To discuss the clinical and pathological characteristics of paraganglioma of urinary bladder and its differential diagnosis. Methods： A case of paraganglioma of urinary bladder was observed with HE , immunohistochemical stains and literature review. Results： The tumor usually occurred in adult female in China, but male in western country. Haematuria and intermittent hypertension during micturition were the usual clinical signs along with generalized symptoms due to raised catecholamines such as headache, blurred vision, heart palpitation and flushing. The histological appearance was similar to that of the adrenal gland. Immunohistochemically, the tumor cells were positive for CgA, Syn, Vimentin, S - 100 protein and NSE. Conclusion： Paraganglioma of urinary bladder is a rare tumour of the bladder which needs to be fully investigated before embarking on any surgical procedure. Prior cystoscopy and partial cystectomy are strongly recommended in order to achieve complete resection due to its multilayer involvement of the bladder wall. The definite diagnosis depends on clinical symptoms, pathology and immunohistochemistry.

关 键 词：副神经节瘤 膀胱 鉴别诊断 

分 类 号：R737.14[医药卫生—肿瘤]