COX-2和Fas在宫颈癌中的表达及其临床意义  

Expression and clinical significance of cyclooxygenase-2 and Fas in cervical carcinoma

作　　者：刘锐[1] 李明众[1] 葛玲[2] 

机构地区：[1]西安交通大学第一附属医院,陕西西安710061 [2]西安交通大学医学院生殖医学研究中心,陕西西安710061

出　　处：《现代肿瘤医学》2008年第2期271-273,共3页Journal of Modern Oncology

摘　　要：目的:研究COX-2和Fas在宫颈癌中的表达及其与临床病理特征间的关系。方法:采用免疫组化S-P方法检测61例宫颈组织(正常宫颈组织10例,宫颈上皮内瘤样变10例,宫颈癌41例)中COX-2和Fas的表达情况。结果:COX-2和Fas在宫颈癌和正常宫颈组织中及CIN中的表达有显著性差异(P<0.05)。COX-2阳性表达和宫颈癌病理分级、淋巴结转移显著相关(P<0.05);Fas阳性表达和淋巴结转移显著相关(P<0.05)。宫颈癌组织中COX-2和Fas的表达呈负相关。结论:COX-2和Fas均参与宫颈癌的发生、发展,在宫颈癌中COX-2的高表达和Fas的低表达均提示有淋巴结转移,可作为判断宫颈癌侵袭性的生物学指标。Objective：To investigate the role of cyclooxygenase -2 （COX -2 ） and fas in the occurrence and development of cervical lesion. Methods： The expression of COX -2 and FAS were tested using immunohistochemical technique. Results： There were significant differences in positive expression of COX -2 and Fas in different cervical tissues （P 〈 0.05 ）. the positive expression of COX -2 was associated with histologic grade and lymphnode metastasis;the positive expression of Fas was associated with histologic grade;the expression of COX -2 and Fas were negatively related in cervical carcinoma. Conclusion ： In cervical carcinoma, the high expression of COX - 2 and the low expression of Fas hinted the possibility of lymphnode metastasis and could be treated as the biological parameter to judge the invasion of cervical carcinoma.

关 键 词：COX-2 FAS 宫颈癌 免疫组化 淋巴结转移 

分 类 号：R737.33[医药卫生—肿瘤]