22例鼻咽非霍奇金淋巴瘤临床分析  

Clinical analysis of 22 patients with nasopharyngeal non-Hodgkin' s lymphoma

作　　者：黎佳全[1] 曾嵘[1] 杨权烈[1] 

机构地区：[1]广东省梅州市人民医院,广东梅州514031

出　　处：《现代肿瘤医学》2008年第2期300-301,共2页Journal of Modern Oncology

摘　　要：目的:分析鼻咽非霍奇金淋巴瘤的发病率、治疗方法、疗效及预后。方法:对22例鼻咽非霍奇金淋巴瘤的临床资料进行回顾性分析。结果:误诊率为90.9%,治疗后CR12例,PR8例,PD2例,有效率(CR+PR)为90.9%。第1年死亡5例,其中高度恶性占62.5%、T细胞占40.0%、有B症状占50.0%、Ⅲ期4例、Ⅱ期1例;3年生存率为72.7%(16/22),5年生存率为63.6%(14/22)。存活5年以上的病例均为无B症状,低、中度恶性及Ⅰ、Ⅱ期病例,B细胞占78.6%。化疗加局部放射治疗占85.7%。结论:鼻咽非霍奇金淋巴瘤占同期恶性淋巴瘤的4.68%,占结外淋巴瘤的16.67%,临床极易误诊,高度恶性、T细胞、有B症状者预后较差,分期越早预后越好,化疗加局部放射治疗预后较好。Objective：To analyse the incidence rate, treated method, clinical effect and prognosis of primary nasopharyngeal non -Hodgkin＇s lymphoma（NPL）. Methods： The clinical and histopathological data of 22 patients with NPL were reviewed retrospectively. Results： The misdiagnostic rate was 90.9%. The overall response rate （CR ＋ PR） was 90.9% ,with CR 12 cases,PR 8 cases and PD 2 cases. 5 cases died winthin 1 year,high grade in 62.5%, T cell tumour in 40.0% ,B symptoms in 50.0% ,4 cases of Ⅲ and 1 case of Ⅱ.3 -year survival rate was 72.7% （16/22） ,5 -year survival rate was 63.6% （14/22）. All the patients who survived more than 5 -year were those with no B symptoms, low and middle grade,stageⅠ and Ⅱ. cases of B cell tumour in 78.6% and cases of chemotherapy plus radiotherapy in 85.7%. Conclusion ： NPL was present in 4.68% of the malignant lymphoma, and 16.67% of extra - nodal lymphoma, it was easily misdiagnosed . The prognosis of those with high grade or T cells tumour and complicated with B symptoms was bad. The prognosis of patients who were in early stage was better. The prognosis of patients treated with chemotherapy plus radiotherapy was better.

关 键 词：非霍奇金淋巴瘤 鼻咽部 治疗 预后 

分 类 号：R739.63[医药卫生—肿瘤]