苏木醇提物对重症肌无力患者干扰素-γ水平的影响  

Effects of ethanol extracts of Caesalpinia Sappan L on IFN-γ in myasthenia gravis

作　　者：李新军[1] 高力[1] 熊跃均[1] 

机构地区：[1]四川省自贡市第四人民医院,四川省自贡市643000

出　　处：《国际神经病学神经外科学杂志》2007年第6期507-509,共3页Journal of International Neurology and Neurosurgery

摘　　要：目的观察苏木醇提物治疗重症肌无力(MG)患者的乙酰胆碱受体抗体(AChRab)、干扰素-γ(IFN-γ)水平变化,探讨苏木醇提物治疗MG可能的免疫机制。方法采用ELISA法对苏木治疗组和常规治疗组MG患者治疗前、后及30例正常对照组外周血AChRab、IFN-γ水平进行检测并作分析。结果①苏木治疗组与常规治疗组MG患者血清ACh-Rab水平治疗前后均较正常对照组显著升高(P<0.05),苏木治疗组与常规治疗组MG患者治疗前血清AChRab水平比较差异无显著性意义(P>0.05),而治疗后差异有显著性意义(P<0.05);②苏木治疗组与常规治疗组MG患者血清IFN-γ水平治疗前后均较正常对照组显著升高(P<0.05),苏木治疗组与常规治疗组MG患者治疗前血清IFN-γ水平比较差异无显著性意义(P>0.05),治疗后差异有显著性意义(P<0.05)。结论苏木醇提物可能通过降低IFN-γ水平从而减少血中AChRab的生成,缓解肌无力症状。Objective This study examined the changes of acetylcholine receptor antibody （AChRab） and γ-interferon （IFN-γ） in patients with myasthenia Davis treated with ethanol extracts of Caesalpinia Sappan L, in order to explore possible immunological mechanisms of ethanol extracts of Caesalpinia Sappan L for the treatment of myasthenia gravis. Methods Blood levels of AchRab and IFN- γwere measured using enzyme-linked immunosorbentassay （ELISA） in 69 patients with myasthenia Davis, including an ethanol extracts of Caesalpinia Sappan L therapy group （ n = 34） and a conventional therapy group （ n = 35 ） and in 30 normal control. Results Blood levels of AchRab and IFN-γin the ethanol extracts of Caesalpinia Sappan L therapy and conventional therapy groups were signifi- candy higher than in the normal control group （ P 〈 0.05 ） before and after treatment. There were no significant differences in the blood levels of AchRab and IFN-γ between the two therapy groups before treatment, but after treatment the blood levels of AchRab and IFN-γin the ethanol extracts of Caesalpinia Sappan L therapy group were significantly lower than those in the conventional therapy group （P 〉 0.05 ）. Conclusions Ethanol extracts of Caesalpinia Sappan L relieve amyasthenia possibly through reducetion of blood levels of IFN-γ and AchRAb in patients with myasthenia gravis.

关 键 词：重症肌无力 苏木醇提物 乙酰胆碱受体抗体 干扰素-Γ 

分 类 号：R746.1[医药卫生—神经病学与精神病学] R512.62[医药卫生—临床医学]