胃癌侵犯胃裸区与CD34、VEGF、VEGF-C表达的关系及临床意义  

Clinical significance and relationship between gastric bare area involved in gastric carcinoma and expression of CD34,VEGF and VEGF-C

作　　者：程鑫[1] 韩明[2] 张仕状[1] 董鹏[1] 曲林涛[1] 

机构地区：[1]潍坊医学院医学影像学系,山东省潍坊市261042 [2]潍坊医学院基础医学教学部,山东省潍坊市261042

出　　处：《世界华人消化杂志》2007年第36期3860-3863,共4页World Chinese Journal of Digestology

基　　金：国家自然科学基金;No.30772716

摘　　要：目的:检测胃癌组织中CD34、VEGF、VEGF-C表达情况,探讨CD34、VEGF、VEGF-C表达与胃癌是否侵犯胃裸区的关系及临床意义.方法:将72例胃癌组织分成胃裸区受侵组与未受侵组,采用免疫组化方法测定其CD34、VEGF、VEGF-C表达情况.结果:胃裸区受侵组与未受侵组胃癌组织的CD34(61.67±21.33 vs 60.79±22.04)、VEGF(27/32 vs 28/40)、VEGF-C(23/32 vs 26/40)的表达无明显差异,近侧胃癌中,胃裸区受侵组与未受侵组胃癌组织的CD34(62.48±20.12 vs 61.79±23.68)、VEGF(23/30 vs 6/9)、VEGF-C(20/30 vs 6/9)的表达无明显差异.结论:胃裸区是否受侵与胃癌组织的CD34、VEGF、VEGF-C的表达无关,胃裸区这一解剖结构可能是胃癌预后较差的原因.AIM： To detect the expression of CD34, vascular endothelial growth factor （VEGF） and vascular endothelial growth factor C （VEGF-C） in gastric carcinoma, and to investigate the clinical significance and relationship between the gastric bare area （GBA） involved in gastric carcinoma and expression of CD34, VEGF and VEGF-C. METHODS： Seventy-two cases of gastric carcinoma were divided into GBA/nvolved and non- involved groups. Expression of CD34, VEGF and VEGF-C was detected by immunohistochemistry. RESULTS： In gastric carcinoma, there was no significant difference in the expression of VEGF （27/32 vs 28/40）, CD34（61.67 ± 21.33 vs 60.79 ± 22.04） or VEGF-C （23/32 vs 26/40） in GBA involved and non-involved groups. In proximal gastric carcinoma, there was no significant difference in the expression of VEGF （23/30 vs 6/9）, CD34 （62.48 ± 20.12 vs 61.79 ± 23.68） and VEGF-C （20/30 vs 6/9） in GBA involved and non-involved groups. CONCLUSION： There was no relationship between the GBA involved in gastric carcinoma and expression of CD34, VEGF and VEGF-C. The anatomical structure of the GBA may result in poor prognosis of gastric carcinoma.

关 键 词：胃癌 胃裸区 CD34 血管内皮生长因子 淋巴管内皮生长因子 

分 类 号：R735.2[医药卫生—肿瘤]