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作 者:高洪文[1] 王功伟[1] 陈世范[1] 姚敏[1] 武艳[1] 王伟华[2] 赵雪俭[2]
机构地区:[1]吉林大学第二医院病理科,吉林130041 [2]吉林大学前列腺疾病防治中心
出 处:《中国男科学杂志》2007年第12期21-24,共4页Chinese Journal of Andrology
基 金:国家科技部国际科技合作重点项目(编号2004DFB02000)
摘 要:目的通过对中国长春市和日本名取市集团筛查前列腺癌对比性研究,揭示两国人群中前列腺癌病理学特征。方法长春市15 192名和名取市4 444名人群中50岁以上的男性应用血清PSA检测进行前列腺癌的集团筛查,对血清PSA含量>4.0ng/ml阳性候选者行前列腺穿刺活检。结果(1)长春市人群中筛状腺癌为42.4%(42/99),名取市为18.3%(21/115)(P<0.01);长春市人群中小腺泡腺癌为29.3%(29/99),名取市为73.9%(85/115)(P<0.01);(2)长春市人群中低分化腺癌为64.7%(64/99),名取市24.3%(28/ 115)(P<0.01),长春市中分化腺癌为33.3%(33/99),名取市为72.2%(83/115)(P<0.01);(3)长春市人群中43.4%(43/99)的腺癌出现神经周围浸润,而名取市为7.0%(8/115)(P<0.01);长春市人群中11.1%(11/99)腺癌出现被膜浸润,而名取市未发现被膜浸润(P<0.01)。结论(1)长春市人群中前列腺腺癌较名取市以低分化癌为主;(2)长春市人群中进展期前列腺癌较名取市人群中多。Objective To reveal the pathological features of the prostate cancer in cohort of Chinese and Japanese through comparable study of prostate cancer by mass screening in Changchun, and Natori. Methods 15 192 Chinese and 4 444 Japanese men aged 50 and over were checked by PSA-based screening in Changchun and Natori. All men with the serum PSA value greater than 4.0ng/ml were recommended for a prostate biopsy. Results (1) Cribriform type adenocarcinoma in cohort accounted for 42.4% (42/99) and 18.3% (21/115) in Changchun and Natori, respectively (P〈0.01). Small gland type adenocarcinoma accounted for 29.3% (29/99)in Changchun cohort, compared with 73.9%(85/115) in Natori (P〈0.01). (2) The moderately differentiated adenocarcinoma accounted for 33.3%(33/99) and 72.2%(83/115) in Changchun and Natori, respectively (P〈0.01). The poorly differentiated adenocarcinoma accounted for 64.7%(64/99) and 24.3%(28/115) in Changchun and Natori, respectively (P〈0.01). (3) Perineural invasion was found in the 43.4%(43/99) cases of prostate cancer in cohort of Changchun compared with 7.0%(8/115) in Natori(P〈0.01). The detection rate of capsule invasion of prostate cancer was 11.1%(11/99) in Changchun and there was no one to have been found in Natori (P〈0.01). Conclusion (1) The poorly differentiated prostate cancer in Changchun cohort are greater than that in Natori. (2) The advanced prostate cancer in Changchun cohort are greater than that in Natori.
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