江苏省肿瘤低发区主要恶性肿瘤危险因素配对病例对照研究  

A Matched Case-control Study on Risk Factors for Common Cancer in Low Incidence Area of Jiangsu Province,China

作　　者：王靖元 朱丽 王旭善[3] 吴德林[3] 李大罕[3] 张晓峰[3] 顾绍升[3] 武鸣[4] 赵金扣[4] 

机构地区：[1]赣榆县卫生局,江苏赣榆222100 [2]赣榆县人民医院,江苏赣榆222100 [3]赣榆县疾病预防控制中心,江苏赣榆222100 [4]江苏省疾病预防控制中心,江苏南京210009

出　　处：《中国肿瘤》2008年第1期5-7,共3页China Cancer

基　　金：江苏省医学135工程重点人才研究基金(RC200390)

摘　　要：[目的]探讨江苏省恶性肿瘤低发地区主要肿瘤有关危险因素。[方法]在江苏省恶性肿瘤低发的赣榆地区进行了以人群为基础的肿瘤1∶1配对病例对照研究,应用条件Logistic回归对相关因素进行单因素和多因素分析。[结果]食管癌和胃癌的共同危险因素为进食快(OR食管=1.95,OR胃=1.46)、热烫饮食(OR食管=2.72,OR胃=2.21)、癌症家族史(OR食管=2.02,OR胃=2.29);对于肺癌而言,吸烟越早(OR=3.63)、烟龄越长(OR=4.13)、吸进部位越深(OR=2.79)均能增加患病概率;饮茶是食管癌(OR=0.73)、胃癌(OR=0.37)、肺癌(OR=0.60)和肝癌(OR=0.27)的共同保护因素,而生吃大蒜对食管癌(OR=0.68)和胃癌(OR=0.64)的保护作用比较确切。[结论]本次研究所发现的有关结果可以为江苏省肿瘤低发及高发地区的防治工作提供参考。[Purpose] To explore the common risk factors of cancer in low cancer incidence area in Jiangsu Province. [Methods] A population based 1：1 matched case-control study was conducted in Ganyu County, one of the low cancer incidence areas in Jiangsu. Conditional Logistic regression method was used to identify associated risk and protective factors. [Resultsl For esophageal and stomach cancer, the common risk factors were the habits of speed meal （OR esophageal=l.95,OR stomach=l.46）, hot food more （OR esophageal=2.72,OR stomach=2.21） and the cancer family history （OResophageal= 2.02,OR stomach=2.29）. As lung cancer, the earlier （OR=3.63）, longer-term（OR=4.13） and heavier （OR=2.79） smoking, the higher cancer occurence. Tea was the common protective factor for esophageal （OR=0.73）, stomach（OR=0.37）, lung（OR=0.60） and liver （OR=0.27）cancers, garlic was protective factor for preventing esophageal （OR=0.68） and stomach （OR=0.64） cancer. [ Conclusion ] The risk fac- tors for cancer attributed to this study may provide a guide for cancer prevention in Jiangsu Province.

关 键 词：肿瘤 病例对照研究 危险因素 流行病学 江苏 

分 类 号：R73-31[医药卫生—肿瘤]