26万女性队列人群中乳腺癌与人工流产关系的研究(上海)  

Breast Cancer in Relation to Induced Abortions in a Cohort of 267040 Women in Shanghai

作　　者：高道利[1] 叶展 秦勤 Ray RM Thomas DB 王文婉[1] 

机构地区：[1]复旦大学附属中山医院分部肿瘤流行病学研究室,上海1200052 [2]美国Fred Hutchinson癌症研究中心

出　　处：《国际生殖健康／计划生育杂志》2008年第1期51-53,64,共4页Journal of International Reproductive Health/Family Planning

摘　　要：目的:评估人工流产(指手术流产)对乳腺癌危险性的可能影响。方法:研究在上海267040例妇女的一项乳房自我检查随机试验的队列人群中进行,由队列研究和巢式病例对照研究两部分组成。结果:依据基线调查表采集的资料分析,人工流产不增加乳腺癌危险性。调整潜在的混淆因素后,OR=1.06(95%CI:0.91～1.25)。人工流产次数增加无危险性趋势增加。从更详细的652例乳腺癌病例和694例对照资料分析,得出相似的结果。人工流产发生在首次生育后不增加危险性;少数妇女在首次生育前人工流产以及妊娠13周后人工流产,虽然被观察到危险性有增加,但无显著性统计学意义。结论:在中国,人工流产不是乳腺癌发生的重要原因。Objective： Evaluation of the possible influence of induced abortion on breast cancer risk. Methods： The study was in a cohort of 267040 women enrolled in a Randomized Trial of Breast Self-examination in Shanghai. The study consisted of two parts： a cohort study and a case-control study nested within the cohort. Results： Based on answers to a baseline questionnaire, subsequent breast cancer risk was not significantly associated with ever having had an induced abortion. After adjustment for potential confounders, the relative risk estimate was 1.06 （ 95% CI： 0.91-1.25 ）, and there was no trend toward a correlation in risk with the number of abortion. Analysis of data from more detailed interviews of 652 cases and 694 controls from the cohort yielded similar results. There was also no overall increase in risk for in women who had an induced abortion for their first birth. A few women had undergone an abortion after 13 weeks of gestation or before their first child. Although an increase in risk was observed in such women, the increase was not statistically significant. Condusions： Abortions as they have been performed in China are not an importan risk factor of breast cancer.

关 键 词：人工流产 乳腺癌 队列研究 巢式病例对照研究 

分 类 号：R737.9[医药卫生—肿瘤] R169.42[医药卫生—临床医学]