癌变组织可见光反射光谱测量  

Visible Light Reflectance Spectrum for Measurement of Cancerous Tissue

作　　者：王成[1] 范瑾[2] 任秋实[2] 

机构地区：[1]上海理工大学生物医学与视光学研究所,上海200093 [2]上海交通大学激光与光子生物医学研究所,上海200240

出　　处：《光谱学与光谱分析》2008年第1期33-36,共4页Spectroscopy and Spectral Analysis

基　　金：上海市教育发展基金(2007CG62)资助

摘　　要：实现在体、实时、无损的早期癌变检查是人们一直努力的方向。通过对几组样本的显微切片观察得出癌症的确切诊断,然后通过癌变组织和同体正常组织的光谱比较,得到癌变组织的可见光反射光谱特性。发现癌变组织的血红蛋白和去氧血红蛋白的增加是导致反射光谱谱线改变的主要因素。组织癌变后在可见光谱范围反射较正常组织的低,在630nm处发生了较强烈的吸收变化。光谱中吸收峰值表明了癌变组织中含有丰富的血红蛋白和去氧血红蛋白,这与癌变组织的组织特性一致,实验上表明了可见光反射光谱能区分正常组织和癌变组织。A goal the authors always pursue is to realize diagnosis of precancer in vivo, real-time and non-invasive. In the present paper, results of diagnosis of certain cancer were obtained by pathological analysis of several samples, and then the visible light reflectance spectrum property of cancerous tissue was acquired by the comparison with the reflectance spectrum of normal tissue in the same organ. It was found that the main result of change in the reflectance spectrum was caused by the increases in hemoglobin and deoxygenated hemoglobin. The cancerous tissue has a lower reflectance in visible spectrum and has the strongest change in the absorption at 630 nm. Absorption peaks in the reflectance spectrum indicated that there are abundant of oxygenated hemoglobin and deoxygenated hemoglobin in the cancerous tissue. It is the same characteristics as in the cancerous tissue. It was fully indicated experimentally that visible light reflectance spectrum can distinguish normal and cancerous tissue.

关 键 词：反射光谱 组织光学 癌症 测量 

分 类 号：R730.4[医药卫生—肿瘤]