不同剂量卡马西平在家兔体内的药物动力学  

Pharmacokinetics of carbamazepine in different doses

作　　者：钟明康[1] 张静华[1] 王宏图[1] 印绮平[1] 余自成[1] 

机构地区：[1]上海医科大学华山医院

出　　处：《中国医院药学杂志》1997年第6期243-245,共3页Chinese Journal of Hospital Pharmacy

摘　　要：本文采用高效液相法（ＨＰＬＣ）测定了卡马西平的血药浓度，在１８只家兔体内观察不同剂量下药物浓度变化和药动学参数差异。结果发现家兔在两种剂量下均有双峰现象，这一现象估计与肠－肝循环有关，两组剂量的Ｔ１／２间有显著差异，高剂量组的平均Ｔ１／２比低剂量的下降一半。The serum carbamazepine level and pharmacokinetics was studied by HPLC in 18 rabbits.The results showed that a double waves phenomenon was found in the two group,which might be related to a circulation between intestine and liver,and the average elimination time in high does group was a half of that in low dose group.

关 键 词：卡马西平 药物动力学 剂量 抗癫痫药 

分 类 号：R971.6[医药卫生—药品]