地稔总酚胃内漂浮片制备工艺的研究  

Study on preparation of phenols gastric floating tablet

作　　者：翟小玲[1] 倪健[1] 谷雨龙[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中国中药杂志》2008年第1期31-34,共4页China Journal of Chinese Materia Medica

摘　　要：目的：优选地稔总酚胃内漂浮片的制备工艺。方法：选择Ⅳ丙烯酸树脂、HPMCK4M,MCC101、十八醇为辅料,干法直接压片,以体外漂浮性能和体外释放性能为指标筛选地稔总酚胃内漂浮片的处方,并进一步研究压片压力对体外漂浮性能和体外释放性能的影响。结果：地稔总酚胃内漂浮片的最优处方和工艺为：地稔总酚有效部位、Ⅳ丙烯酸树脂和十八醇分别为处方比例的31%,MCC101为7%,加硬脂酸镁适量,干法直接压片,控制压力3~4 kg。结论：该工艺重现性好,为地稔总酚胃内漂浮片的制备提供依据。Objective： To study the preparation of phenols gastric floating tablet.Method： The tablets which were prepared using Eudragit Ⅳ,HPMCK4M,MCC101 and Octadecanol as excipients were evaluated by vitro floatation and releasing performance.The pressure of preparationg was also study to select the optimal preparation.Result： The tablets were successfully prepared in which the drug,Eudragit Ⅳ,Octadecanol were 31% respectively,and MCC101 was 7%.And 3-4 kg was found to be the eligible pressure.Conclusion： The study was found to be effective in the process of phenols gastric floating tablet.

关 键 词：地稔 总酚 胃内漂浮片 

分 类 号：TQ461[化学工程—制药化工]