转化生长因子β_1在口腔粘膜下纤维性变角朊细胞中的表达  

Expression of transforming growth factor β 1 in keratinocytes of oral submucous fibrosis tissue

作　　者：高义军[1] 凌天牖[1] 吴汉江[1] 李运良[1] 

机构地区：[1]湖南医科大学附属第二医院口腔科

出　　处：《中华口腔医学杂志》1997年第4期239-241,共3页Chinese Journal of Stomatology

摘　　要：为探讨转化生长因子β１在口腔粘膜下纤维性变发病机理中的作用，作者应用原位杂交方法，对２５例口腔粘膜下纤维性变（ｏｒａｌｓｕｂｍｕｃｏｕｓｆｉｂｒｏｓｉｓ，ＯＳＦ）、５例正常口腔粘膜（ＮＯＲ）及１０例口腔扁平苔藓（ｏｒａｌｌｉｃｈｅｎｐｌａｎｕｓ，ＯＬＰ）组织角朊细胞中转化生长因子β１（ｔｒａｎｓｆｏｒｍｉｎｇｇｒｏｗｔｈｆａｃｔｏｒβ１，ＴＧＦβ１）ｍＲＮＡ进行了检测。结果：１５例（６０％）ＯＳＦ组织角朊细胞中有ＴＧＦβ１ｍＲＮＡ表达，阳性表达主要分布于早、中期ＯＳＦ组织角朊细胞中；５例ＮＯＲ及１０例ＯＬＰ组织角朊细胞表达呈阴性。结果提示：ＯＳＦ组织角朊细胞可合成分泌ＴＧＦβ１，ＴＧＦβ１在ＯＳＦ的发病机理中可能起重要作用，可能作为一中间介质参与了ＯＳＦ的发病过程。To explore significance of transforming growth factor β 1 (TGF β 1) in the pathogenesis of oral submucous fibrosis (OSF), TGF β 1 mRNAs in keratinocytes of the paraffin embeded tissues of 25 OSF cases, 5 normals (NOR) and 10 oral lichen planus (OLP) were determined by the in situ hybridization technique. The result showed that there was an expression of TGF β 1 mRNA in keratinocytes of 15 OSFs (60%). The positive expression of TGF β 1 mRNA was mainly in kerationcytes of early and middle stage OSF. There was no expression in that of 5 NORs and 10 OLPs. The study suggests that keratinocyte of OSF tissue may synthesize and release TGF β 1 which may play an important role in the pathogenesis of OSF and participate as a mediator in the pathogenetic process of OSF.

关 键 词：口腔粘膜下 纤维性变 角朊细胞 TGFΒ1 OSF 

分 类 号：R781.5[医药卫生—口腔医学]