乙型和丙型肝炎病毒感染与肝细胞癌  

Hepatitis B and Hepatitis C virus infection and hepatocellular carcinoma

作　　者：魏金荣[1,2] 刘金兰[1,2] 张玉魁[1,2] 张岐山[1,2] 

机构地区：[1]中国医科大学基础医学院 [2]中国医科大学第一临床学院

出　　处：《中华传染病杂志》1997年第3期151-153,共3页Chinese Journal of Infectious Diseases

摘　　要：为探讨乙型和丙型肝炎病毒（ＨＢＶ和ＨＣＶ）感染与肝细胞癌（肝癌）发生的关系，采用ＥＬＩＳＡ和聚合酶链反应（ＰＣＲ）对沈阳地区１１７例肝癌、１０７例肝硬化和４５例血液透析患者血清进行了ＨＢＶ和ＨＣＶ血清标志及ＨＢＶＤＮＡ和ＨＣＶＲＮＡ检测，并采用限制性片段长度多态性对其中７３例ＨＣＶＲＮＡ阳性血清进行了ＨＣＶ基因分型。结果，肝癌组ＨＢＶ感染率（６０７％）显著高于ＨＣＶ感染率（３３３％，Ｐ＜００１），肝硬化组ＨＢＶ感染率（４３９％）明显高于ＨＣＶ感染率（２９０％，Ｐ＜００５）；血液透析组ＨＢＶ和ＨＣＶ重叠感染率（２６７％）明显高于肝硬化组（１０３％，Ｐ＜００５）；各组均以ＨＣＶⅡ型为主（６５２％～８００％），ＨＣＶⅢ型次之（２００％～３１４％）。结果提示：沈阳地区肝癌的诱发因素仍以ＨＢＶ为主，血液透析患者ＨＢＶ和ＨＣＶ重叠感染的机会更大，ＨＣＶⅡ型感染在本地区ＨＣＶ相关性肝癌和肝硬化的发生中可能起主要作用。In order to study the relationship between HBV and HCV infection and hepatocellular carcinoma, ELISA and PCR techniques were used to detect the serologic markers of HBV and HCV,HBV DNA and HCV RNA of 117 patients with hepatocellular carcinoma (HCC), 107 patients with liver cirrhosis (LC) and 45 hemodialysis (HD) patients from Shenyang area. 73 HCV RNA positive sera from the 269 patients were analyzed by restriction fragment length polymorphism. Data showed that the infection rate of HBV was significantly higher than that of HCV in HCC group (60 7% vs 33 3% P<0 01) as well as in LC group (43 9% vs 29 0% P<0 05). Co infection rate of HBV and HCV of HD group (26 7%) was significantly higher than that of LC group (10 3%, P<0 05). HCV genotypes of all groups were mainly of type Ⅱ (65 2%～80 0%) whereas that of type Ⅲ were 20 0%～31 4%. These results indicated that HBV is still the main pathogenetic factor of HCC in Shenyang area. Co infection rate of HD patients is higher than others. The infection of HCV type Ⅱ appears to play a main role in the development of HCV associated HCC and LC in this area.

关 键 词：肝炎病毒 肝肿瘤 

分 类 号：R735.702[医药卫生—肿瘤]