肿瘤及对照人群血清细小病毒H1抗体检测  

The detection of antibodies to parvovirus h1 in sera from cancer patients and normal adults

作　　者：沈锡中[1,2] 萧树东[1,2] 江绍基[1,2] 

机构地区：[1]上海第二医科大学附属仁济医院,200001 [2]上海市消化疾病研究所,200001

出　　处：《上海医学》1997年第8期443-445,共3页Shanghai Medical Journal

摘　　要：细小病毒能抑制自发和诱发的肿瘤形成，具有明显的抗肿瘤作用。人群血清流行病学研究表明细小病毒AAV感染和宫颈癌的低发生率有关。本文用血凝抑制试验检测肿瘤患者和健康对照人群血清细小病毒H1抗体。结果表明，414例肿瘤患者血清中3例抗细小病毒H1抗体阳性（0．75％），对照血清420例中有21例阳性（5．0％）。肿瘤患者血清细小病毒H1抗体阳性率明显低于对照人群（P＜0．001）。提示细小病毒H1感染可能影响人群恶性肿瘤的发生。Certain epidemiological data are campatible with the possibility that an inverse correlation has been established between the risk of cancer, namely cervical carcinoma, and the seropositivity index reflecting prior AAV virus iofection. In this study, sera antibody against parvovirus H-1 was detected by he maggl u t ina tion-inhibition tests. 21 out of 420 sera (5. 0%)from normal adults were found positive, but only 3 out of 4l4 sera (0. 75%) from various human cancer patients were positive. The difference in positivity between two groups appears highly significant (P<0. 001).The significance is not clear but may suggest parvovirus H-1 giving some protection against carcinogenesis in human being.

关 键 词：细小病毒H1 抗体检测 肿瘤 宫颈肿瘤 

分 类 号：R730.1[医药卫生—肿瘤] R737.330.1[医药卫生—临床医学]