糖基化突变体细胞引发疾病的研究进展  

Study on the Diseases Induced by Glycosylation Mutant Cells

作　　者：赵安幸[1] 金拓[2] 

机构地区：[1]上海交通大学生命科学技术学院,上海200240 [2]2上海交通大学药学院,上海200240

出　　处：《现代生物医学进展》2008年第2期361-363,共3页Progress in Modern Biomedicine

摘　　要：糖基化是细胞表面最常见也是最重要的一种修饰方法,异常的糖基化会影响糖基化产物的结构,改变细胞表面的化学特性;利用基因技术和化学小分子,调控糖基化酶的活性,可以人为地影响糖基化反应进程,揭示糖基化产物对生物体健康的影响,展示糖基化突变体与疾病的关联。Glycosylation is one of the most common and most important methods to modify cell surfaces. Glycosylation mutants often influence the products＇ structure and change chemical characteristics of cell surfaces. Regulation of the activity ofglycosylation-related enzyme through genetic methods and small chemical molecules will alter glycosylation process and disclose the impact of glycosylation products on organism health and the relationship between glycosylation mutants and diseases.

关 键 词：糖基化突变体 糖基转移酶 糖苷酶 疾病 

分 类 号：R363[医药卫生—病理学]