气相色谱法测定复方氨息香酊中樟脑和薄荷脑的含量  

Determination of the Content of Camphor and Mentholum in Compound Benzoic Acid Tincture by GC

作　　者：李水廷[1] 毕雪艳 郭瑞锋[2] 郄冰冰[2] 董桂敏 

机构地区：[1]河北省邯郸市药品检验所,河北邯郸056001 [2]河北省药品检验所,河北石家庄050011 [3]华北制药新药研发中心,河北石家庄050015 [4]不详

出　　处：《解放军药学学报》2008年第1期84-85,共2页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的采用气相色谱法(GC)测定樟脑和薄荷脑的含量。方法色谱柱为10%PEG-20M(0.25mm×30m,0.25μm),柱温150℃,采用FID检测器,进样口温度200℃,检测器温度200℃,萘为内标。结果薄荷脑和樟脑均在0.4～1.6mg·ml-1范围内线性关系良好,r分别为0.9995、0.9998,平均回收率分别为99.14%、99.04%,RSD分别为0.3%、0.3%。结论该质量标准的研究有效控制了复方氨息香酊的质量,方法简单、结果准确、灵敏度高。AimA GC method was developed to determine the content of camphor and mentholum. Methods The column was packed with 10% PEG-20M（0.25mm×30m,0.25μm）. The column temperature was 150℃. The detector was FID. The injector temperature was 200℃ and the detector temperature was 200℃. Naphthalene was used as the internal standard. Results The linear relation of the peak area of camphor was determined as 0.4 - 1.6mg· ml^-1 by GC with a regression coefficient of 0.999 5 and average recovery rate 99.14%, RSD =0.3% ,while that of mentholum was determined as 0.4 - 1.6mg·ml^-1 by GC with a regression coefficient of 0.999 8 and average recovery rate 99.04%, RSD =0.3%. Conclusion The method is simple,rapid and accurate. It can be used for the determination of camphor and mentholum in Compound Benzoic Acid Tincture.

关 键 词：复方氨息香酊 薄荷脑 樟脑 GC 

分 类 号：R927.2[医药卫生—药学]