桔核中柠檬苦素类物质消炎镇痛作用的研究  

An anti-inflammation and Analgesic Experimental Study on Limonoids from Citrus Seeds

作　　者：施英[1] 徐玉娟[1] 吴娱明[1] 温靖[1] 蔡月仙[1] 

机构地区：[1]广东省农业科学院蚕业与农产品加工研究所广东省农产品加工公共实验室,广州510610

出　　处：《天然产物研究与开发》2007年第B11期456-458,共3页Natural Product Research and Development

基　　金：广东省自然科学基金项目（04002072）

摘　　要：为探讨柑桔果实中柠檬苦素类物质对实验动物模型的抗炎镇痛作用，本文通过小鼠耳廓肿胀模型和角叉菜胶致大鼠足肿胀模型观察柠檬苦素的抗炎作用；采用小鼠福尔马林实验及扭体实验观察柠檬苦素的镇痛作用。结果表明：柑桔果实中柠檬苦素类物质能显著抑制二甲苯致小鼠耳廓肿胀和角叉菜胶致大鼠足肿胀程度；减少扭体次数；显著提高小鼠福尔马林实验中的痛域。因此，柑桔果实中柠檬苦素类物质对本实验中的动物模型具有显著的抗炎及镇痛作用。To study the anti-inflammation and analgesic effect of limonoids from citrus seeds, the analgesic effect of limonoids was tested by formaldehyde test and writhing test in mice. The anti-inflammation effect of limonoids was tested by auricle edemata caused by xylol and rats digitolplantar edema caused by carrageenan. The result showed that limonoids from citrus seeds could inhibit the neciceptive response by formalin ,reduce the writhing number, obviously inhibit auricle edemata and digitolplantar edema. So limonoids from citrus fruits had potent anti-inflammation and analgesic effect.

关 键 词：柠檬苦素类物质 桔核 消炎 镇痛 

分 类 号：R284.1[医药卫生—中药学]